Rnd2 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family of GTPases. [5] . It is encoded by the gene RND2. [6] It contributes to regulating the organization of the actin cytoskeleton in response to extracellular growth factors (Nobes et al., 1998). [supplied by OMIM] [7]

2025年3月30日 · RND2 (Rho Family GTPase 2) is a Protein Coding gene. Diseases associated with RND2 include Bosch-Boonstra-Schaaf Optic Atrophy Syndrome and Corpus Callosum, Agenesis Of, With Abnormal Genitalia. Among its related pathways are GPCR Pathway and Signaling by Rho GTPases.

RNA specificity category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.

2021年9月24日 · Here, by using a retrovirus-based loss-of-function approach in vivo, we show that the atypical Rho GTPase Rnd2 is crucial for survival, positioning, somatodendritic morphogenesis, and functional...

摘 要：Rnd2 是 Rho GTPase 超家族下的 Rnd 亚家族中非典型成员之一，且 Rnd2 主要以活性鸟苷三磷酸结合态 存在。 研究表明，Rnd2 通过调节细胞骨架，可在影响细胞的运动与突起的生长在神经元发育以及妊娠的维持等过

Rnd2 regulates neurite outgrowth by functioning as the RhoA activator through Pragmin, in contrast to Rnd1 and Rnd3 inhibiting RhoA signaling; The RND2 mRNA levels increased significantly after gestation in myometria. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers

该基因编码 Rho GTPase 家族的一个成员，其成员在响应细胞外生长因子的肌动蛋白细胞骨架组织调节中发挥关键作用。 这个特殊的家族成员与神经元形态和内体运输的调节有关。 该基因定位于 17 号染色体，是乳腺癌-卵巢癌易感基因 BRCA1 的着丝粒邻居。 [RefSeq 提供，2008 年 7 月] This gene encodes a member of the Rho GTPase family, whose members play a key role in the regulation of actin Cytoskeleton organization in response to extracellular growth factors.

Rnd proteins are mainly involved in the regulation of the actin cytoskeleton and cell proliferation. Whereas Rnd3 is ubiquitously expressed, Rnd1 and 2 are tissue-specific. Increasing data has described their important role during development and diseases.

2020年8月31日 · Our study demonstrated that RND2 functions as an endogenous repressor of the p38 MAPK phosphorylation complex. RND2 physically interacted with p38 and decreased p38 phosphorylation, thereby inhibiting p38 MAPK signalling activities.

本文将详细介绍RND2基因的功能、作用机制、信号通路及其与疾病的关系，帮助读者全面理解这一重要的Rho家族GTPase成员。 RND2，也被称为Rho7或RhoN，是Rho家族GTPases中的一员，位于人类染色体17q21.31上。 这个基因编码的蛋白质在细胞内扮演着关键的角色，特别是在细胞骨架的重塑和细胞迁移过程中。 RND2主要通过调控细胞骨架的动态变化来影响细胞的形态和运动。 它通过与GTP结合，激活下游的信号通路，促使肌动蛋白纤维的重组，从而帮助细胞适应 …