Argonaute - Wikipedia
The Argonaute protein family, first discovered for its evolutionarily conserved stem cell function, [1] plays a central role in RNA silencing processes as essential components of the RNA …
miRNA的功能及其作用机制 - 知乎 - 知乎专栏
(3) argonaute(Ago)是RISC的核心成分，为 miRNA诱导的基因沉默所必需。 Ago含 有两个RNA结合域：PAZ，与成熟 MIRNA的3' 端结合；PIWI，类似核糖核酸酶-H，和引导链5'端结合。
Life of RISC: Formation, action, and degradation of RNA …
2022年1月6日 · To achieve these functions, small RNAs form RNA-induced silencing complex (RISC) together with a member of the Argonaute (AGO) protein family. RISC is directed by its …
RNA-induced silencing complex - Wikipedia
Part of the RNA interference pathway with the different ways RISC can silence genes via their messenger RNA. AGO2 (grey) in complex with a microRNA (light blue) and its target mRNA …
To achieve these functions, small RNAs form RNA-induced silencing complex (RISC) together with a member of the Argonaute (AGO) protein family. RISC is directed by its bound small …
AGO蛋白质 - 百度百科
Argonaute (AGO)：最近的研究表明，PAZ结构域结合到 siRNA 的3’的二 核苷酸 突出端；一些AGO蛋白质的PIWI结构域赋予slicer以内切酶的活性。 PAZ和PIWI两个结构域，对于siRNA和 …
Anatomy of RISC: how do small RNAs and chaperones activate …
This review dissects the currently available structures of AGO proteins and proposes models and hypotheses for RISC assembly, covering the conformation of unloaded AGO proteins, the …
Comprehensive Evolutionary Analysis of the Major RNA …
2018年9月21日 · RNA-induced silencing complex (RISC) plays a critical role in small interfering RNA (siRNA) and microRNAs (miRNA) pathways. Accumulating evidence has demonstrated …
解读AGO蛋白结构及其功能 - 中国生物化学与分子生物学报
RNA沉默是由小RNA特异向导和RNA诱导的沉默复合物（RISC）切割或者抑制靶标mRNA翻译的一种调控系统. 作为RISC的核心成分，AGO蛋白(argonaute proteins)由N末端、PAZ、MID …
RISC 的生命：RNA 诱导的沉默复合物的形成、作用和降 …
To achieve these functions, small RNAs form RNA-induced silencing complex (RISC) together with a member of the Argonaute (AGO) protein family. RISC is directed by its bound small …