RIPK2：治疗炎症性疾病的新靶点 - hanspub.org
Receptor-interacting protein kinase 2 (RIPK2) is a downstream signaling molecule of nucleotide-binding oligomerization domain-containing proteins 1 and 2 (NOD1/2) and plays a cru-cial role …
RIPK2 - Wikipedia
Receptor-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the RIPK2 gene. [5] [6] [7] This gene encodes a member of the receptor-interacting protein …
RIPK2 Gene - GeneCards | RIPK2 Protein | RIPK2 Antibody
2024年12月25日 · RIPK2 (Receptor Interacting Serine/Threonine Kinase 2) is a Protein Coding gene. Diseases associated with RIPK2 include Crohn's Disease and Leprosy. Among its …
Receptor-interacting protein kinase 2 (RIPK2) stabilizes c-Myc
2022年2月3日 · Here we show receptor-interacting protein kinase 2 (RIPK2) is a clinically actionable target for inhibiting PC metastasis. RIPK2 is amplified/gained in ~65% of lethal …
RIPK2 inhibitors for disease therapy: Current status and perspectives
2023年11月5日 · RIPK2 is an upstream regulator of stress-induced caspase-1 activation, which is essential for neuronal death induced by overexpression of RIPK2 [29]. Therefore, RIPK2 is …
RIP kinases as modulators of inflammation and immunity
2018年8月21日 · Receptor-interacting protein (RIP) kinases, in particular RIPK1, RIPK2 and RIPK3, have emerged as pleiotropic modulators of inflammatory responses that act either by …
RIPK2 as a New Therapeutic Target in Inflammatory Bowel Diseases
2021年4月14日 · Receptor-interacting serine/threonine kinase 2 (RIPK2), also known as receptor-interacting protein 2 (RIP2), is a downstream signaling molecule for nucleotide-binding …
项目文章Cancer Discovery | 单细胞测序揭秘胰腺癌免疫治疗靶点RIPK2
该研究应用体内CRISPR筛选确定RIPK2是免疫逃避的关键驱动因素，并通过 新格元 GEXSCOPE® 单细胞转录组测序 (scRNA-Seq)技术 发现CD8+T细胞是PDAC肿瘤免疫微环境 …
Receptor-interacting Protein Kinase 2 Is an Immunotherapy
2024年2月8日 · Our data showed that receptor-interacting protein kinase 2 (RIPK2) is a crucial driver of immune evasion of cytotoxic T-cell killing and that genetic or pharmacologic targeting …
RIPK2 inhibitors for disease therapy: Current status and ... - PubMed
2023年11月5日 · The present study reviews the molecule structure and biological functions of RIPK2, and its correlation between human diseases. In addition, we focus on the structure …