2025年3月30日 · RHOB (Ras Homolog Family Member B) is a Protein Coding gene. Diseases associated with RHOB include Pancreatic Adenocarcinoma and Adenocarcinoma . Among its related pathways are Semaphorin interactions and Signaling by Rho GTPases .

2024年2月19日 · Rho GTPases 是一类重要的细胞信号传导蛋白，在细胞内起着关键的调控作用。 它们是小的 GTP酶，属于 Ras超家族，包括RhoA、RhoB、RhoC、Rac1、Rac2、Cdc42等多种成员。 Rho GTPases通过调节细胞骨架重塑、细胞迁移、细胞黏附、细胞极化和基因转录等过程参与细胞生物学的多个方面。 在这篇综述中，作者提出并讨论了Rho GTPases的自组织能力，即直接从低阶状态过渡到高阶状态。 也讨论Rho GTPase的自组织模式形成对细胞功能的优势。 …

Rho家族蛋白是 Ras超家族 中最早被克隆出来的蛋白，它们是一组 相对分子质量 大约为20～25kD的 三磷酸鸟苷 （guanosine triphosphate，GTP）结合蛋白，具有GTP酶活性，因此，习惯被称为Rho GTP酶，Rho GTP酶在 细胞骨架 重组调控方面起重要作用。 近年来研究发现，Rho GTP酶在多种 恶性肿瘤 中高表达，并和 肿瘤 的发生、侵袭和转移密切相关。 本文主要从 肿瘤细胞 形态改变，细胞与 胞外基质 粘附以及细胞骨架重组等几个方面，对Rho GTP酶作用 …

Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene. [5] [6] RHOB is a member of the Rho GTP-binding protein family. [7]

关于 rhob Cytogenetic location: 2p24.1 Genomic coordinates (GRCh38): 2:20,447,074-20,449,440 (from NCBI) This gene has 1 transcript (splice variant), 190 orthologues and 22 paralogues.

2023年6月1日 · RhoB regulates the endocytic trafficking of signaling molecules and cytoskeleton remodeling, thereby controlling growth, apoptosis, stress response, immune function, and cell motility in various contexts. Some of these functions may be ascribed to RhoB’s unique subcellular localization to endocytic compartments.

RhoB 是 Ras 同源基因家族和 GTPase 的成员，通过与表皮生长因子受体 (EGFR)、Ras 和磷脂酰肌醇 3-激酶 (PI3K)/Akt 接口来调节细胞内信号通路，以调节细胞结构和功能的反应。

2001年11月1日 · RhoB is a small GTPase that regulates actin organization and vesicle transport. It is required for signalling apoptosis in transformed cells that are exposed to farnesyltransferase inhibitors,...

RhoB regulates the endocytic trafficking of signaling molecules and cytoskeleton remodeling, thereby controlling growth, apoptosis, stress response, immune function, and cell motility in various contexts. Some of these functions may be ascribed to RhoB’s unique subcellular localization to endocytic compartments.

RhoB is a 22 kDa small GTPase, a member of the Ras super-family and Rho sub-family of GTPases, that upon activation by a guanine nucleotide exchange factor (GEF), is essential in regulating actin cytoskeletal re-arrangement as a part of a signal transduction pathway transducing extracellular signals (activation of cell surface receptors and ...