RhoG (Ras homology Growth-related) (or ARGH) is a small (~21 kDa) monomeric GTP-binding protein , and is an important component of many intracellular signalling pathways. It is a member of the Rac subfamily of the Rho family of small G proteins [ 5 ] and is encoded by the gene RHOG .

2025年3月30日 · RHOG (Ras Homolog Family Member G) is a Protein Coding gene. Diseases associated with RHOG include Familial Hemophagocytic Lymphohistiocytosis 5 and Lymphoproliferative Syndrome, X-Linked, 2. Among its related pathways are Constitutive Signaling by Aberrant PI3K in Cancer and Signaling by Rho GTPases.

RhoG 是小 GTP 酶 Rho 家族的多面成员，与 Rac 亚家族成员具有最高的序列同一性。 它充当分子开关，激活后在调节免疫细胞的基本过程中发挥核心作用，例如肌动蛋白细胞骨架动力学、跨内皮迁移、存活和增殖，包括炎症期间的免疫功能（例如吞噬作用和吞噬作用 ...

2023年6月28日 · Phagocytosis and trogocytosis are an orchestrated signaling pathway regulated by RhoGTPases like RhoG. RhoG is required for Fcγ Receptor (FcγR) and Complement Receptor 3 (CR3)-mediated phagocytosis. RhoG enables TC21 to regulate TCR-mediated endocytosis, which is critical for T-cell and APC activation modules.

ras 同系物家族成员 G： 该基因编码小 GTP 酶 Rho 家族的一个成员，它在非活性 GDP 结合状态和活性 GTP 结合状态之间循环，并在信号转导级联中充当分子开关。 Rho 蛋白促进肌动蛋白细胞骨架的重组并调节细胞形状、附着和运动。编码的蛋白质促进功能性鸟嘌呤核苷酸交换因子 (GEF) 复合物从细胞质易位 ...

2023年6月28日 · This review focuses on the cellular functions of RhoG, interconnecting different signaling pathways, and speculates the importance of this small GTPase as a prospective target against several pathological conditions.

2025年2月8日 · we show a novel function for the small GTPase RhoG on the regulation of the interferon-gamma promoter and nuclear factor of activated T cells (NFAT) gene. RhoG also promotes T-cell spreading on fibronectin; Results suggest that RhoG contributes to the regulation of Rac1 activity in migrating cells.

rhog是位于11号染色体的基因。 本词条缺少概述图，补充相关内容使词条更完整，还能快速升级，赶紧来 编辑 吧！

2003年1月22日 · RhoG potentiates gene transcription in lymphocytes. RhoG is expressed at high levels in both B and T lymphocytes (data not shown).

RhoG (CAAX = CILL) has the highest sequence similarity to Rac1 (72%) and Cdc42 (62%) and also shares activators, effectors, and biological functions with these proteins [88]. Unlike Rac1, RhoG may be phosphorylated in its hypervariable domain. PKA was capable of phosphorylating RhoG, but not RhoG S187A, in vitro [66]. However, it is unknown if ...