Rho family GTPases and their regulators in lymphocytes
2009年8月21日 · The emerging picture shows that Rho family GTPases transduce signals from receptors for antigens, chemokines and cytokines, as well as adhesion molecules and pattern …
RhoG regulates gene expression and the actin cytoskeleton in ...
2003年1月22日 · RhoG, a member of the Rho family of GTPases, has been implicated as a regulator of the actin cytoskeleton. In this study, we show a novel function for the small …
Frontiers | RhoG’s Role in T Cell Activation and Function
2022年2月24日 · Calcineurin dephosphorylates numerous serine/threonine residues in the regulatory domain of NFAT, causing a conformational shift, nuclear localization signal …
Modulation of NFAT-dependent gene expression by the RhoA …
Here, we show that RhoA is able to inhibit HIV-1 gene expression through the NFAT-binding site in the HIV long-terminal repeat. Constitutively active NFAT counteracts the inhibitory activity of …
Nuclear factor of activated T cells mediates RhoA-induced …
2013年4月1日 · RhoA-induced NFAT activation and fibronectin upregulation were both dependent on the calcium/calmodulin pathway and Rho kinase. NFAT activation was also observed in …
NFAT, immunity and cancer: a transcription factor comes of age
2010年8月20日 · Nature Reviews Immunology - NFAT transcription factors are expressed by most immune cells and have critical roles in regulating immune responses. This Review …
Vav1 and Ly-GDI Two Regulators of Rho GTPases, Function …
2002年12月20日 · One well studied regulator of Rho GTPases is Vav1; a hematopoietic cell-specific guanine nucleotide exchange factor critical for signaling in T cells, including …
RhoG's Role in T Cell Activation and Function - PubMed
2022年2月25日 · The role of NFAT plays in T cell anergy is inducing the transcription of anergy-associated genes, such as IL-2, IL-5, and IFN-γ. Although information about RhoG in T cell …
RhoG's Role in T Cell Activation and Function - ResearchGate
2022年2月25日 · RhoG activity is critical during late T cell activation following antigen –receptor interaction. cells. Despite increase in TCR signalling, cell proliferation is inhibited, implying that …
The GPR55 ligand L-alpha-lysophosphatidylinositol promotes …
We find that treatment with LPI induces marked GPR55 internalization and stimulates a sustained, oscillatory Ca (2+) release pathway, which is dependent on Galpha13 and requires RhoA …