Rho family of GTPases - Wikipedia
The Rho family of GTPases is a family of small (~21 kDa) signaling G proteins, and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate …
重要综述！细胞信号传导蛋白——Rho GTPases - 知乎
2024年2月19日 · Rho GTPases 是一类重要的细胞信号传导蛋白，在细胞内起着关键的调控作用。 它们是小的 GTP酶，属于 Ras超家族，包括RhoA、RhoB、RhoC、Rac1、Rac2、Cdc42等 …
The RHO Family GTPases: Mechanisms of Regulation and Signaling
RHO GTPases contain a highly conserved G domain, which is responsible for GDP/GTP binding and GTP hydrolysis. Switch I and switch II regions are the consensus binding sites for GEFs, …
Rho蛋白_百度百科
Rho家族蛋白是 Ras超家族 中最早被克隆出来的蛋白，它们是一组 相对分子质量 大约为20～25kD的 三磷酸鸟苷 （guanosine triphosphate，GTP）结合蛋白，具有GTP酶活性，因 …
Patterning of the cell cortex by Rho GTPases - Nature
2024年1月3日 · The Rho GTPases — RHOA, RAC1 and CDC42 — are small GTP binding proteins that regulate basic biological processes such as cell locomotion, cell division and …
Regulating Rho GTPases and their regulators - Nature
2016年6月15日 · Rho GTPases, which cycle between a GTP-bound active form and a GDP-bound inactive form, regulate cytoskeletal and cell adhesion dynamics and thus are crucial for …
The RHO Family GTPases: Mechanisms of Regulation and Signaling
2021年7月20日 · It seems that 20 canonical RHO GTPases are likely regulated by three GDIs, 85 GEFs, and 66 GAPs, and eventually interact with >70 downstream effectors. A recurring …
Rho GTPase-activating proteins in cell regulation
The Rho GTPase-activating proteins (RhoGAPs) are one of the major classes of regulators of Rho GTPases found in all eukaryotes that are crucial in cell cytoskeletal organization, growth, …
Structural Dynamics of Rho GTPases - ScienceDirect
2025年2月1日 · Once activated, Rho GTPases relocate to the plasma membrane (PM) or other intracellular compartments to selectively interact with downstream effectors. GTPase …
Rho激酶在免疫细胞及自身免疫性疾病中的研究进展 - 国际免疫学 …
Rho激酶 (Rho-associated kinases，ROCKs)是一种丝氨酸/苏氨酸蛋白激酶，是Rho GTP酶下游重要的效应分子。 Rho GTPase酶能够在与GTP结合的活性状态和与GDP结合的失活状态之间 …