RHEB - Wikipedia
RHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and other mammals. The protein is largely involved in the …
Rheb泛素化调控生长因子诱导的mTORC1激活 - 知乎
作为mTORC1信号通路的关键负调控因子，TSC复合物主要作为GAP使RhebGTPase失活。 然而，作者发现TSC1、TSC2或TBC1D7的表达促进了HEK293T细胞中Rheb的泛素化。 作者使用 …
mTOR 通路 | Cell Signaling Technology
小分子 GTP 酶 Rheb，在与 GTP 结合的状态下，是 mTORC1 激酶活性所需的强效刺激剂，并且受到其 GAP（即结节性硬化异二聚体 TSC1/2）的负性调控。 绝大多数上游输入信号通过 Akt …
Rheb G-Proteins and the Activation of mTORC1 - PMC
While only one Rheb is present in lower eukaryotes, two Rheb proteins exist in mammalian cells. A number of studies establish that one of the functions of Rheb is to activate mTOR leading to …
RHEB Gene - GeneCards | RHEB Protein | RHEB Antibody
5 天之前 · RHEB (Ras Homolog, MTORC1 Binding) is a Protein Coding gene. Diseases associated with RHEB include Focal Cortical Dysplasia, Type Ii and Isolated Focal Cortical …
Mechanisms of mTORC1 activation by RHEB and inhibition by …
2017年12月13日 · Here we present the 3.0 ångström cryo-electron microscopy structure of mTORC1 and the 3.4 ångström structure of activated RHEB–mTORC1. RHEB binds to mTOR …
Rheb regulates nuclear mTORC1 activity independent of …
2022年6月16日 · The small GTPase Ras homolog enriched in brain (Rheb) plays a critical role in activating the mechanistic target of rapamycin complex 1 (mTORC1), a signaling hub that …
RHEB 蛋白, Human (GST) - MCE
RHEB is an important small GTPase that acts as an allosteric activator of the mTORC1 complex, a key nutrient sensor that controls cell growth and biomass production. In response to signals …
Rheb泛素化调控生长因子诱导的mTORC1激活 - 百度
2023年5月5日 · 作为对各种环境信号的响应，mTORC1在溶酶体上通过两种Ras相关的小G蛋白Rheb-和Rag-GTPase相互作用而被激活。 然而，目前关于Rheb活性的调控机制仍知之甚少。
RHEB neddylation by the UBE2F-SAG axis enhances mTORC1 …
2025年1月6日 · Here, we report that RHEB is a substrate of NEDD8-conjugating E2 enzyme UBE2F. In cell culture, UBE2F depletion inactivates mTORC1, inhibiting cell cycle …