2025年3月30日 · RGS10 (Regulator Of G Protein Signaling 10) is a Protein Coding gene. Diseases associated with RGS10 include Schizophrenia and Osteopetrosis. Among its related pathways are GPCR downstream signalling and G-AlphaQ Signaling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity.

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms.

RGS10 is a key molecule that contributes to the inhibition of Galpha-dependent signaling during chemokine-activated alpha4beta1- and alphaLbeta2-dependent T cell adhesion. RGS10 and RGS4 proteins are both detected in postmortem prefrontal cortex.

2020年11月1日 · RGS10 is the smallest protein of the D/R12 subfamily and selectively interacts with Gαi proteins. It is widely expressed in many cells and tissues, with the highest expression found in the brain and immune cells. RGS10 expression is transcriptionally regulated via epigenetic mechanisms.

RGS10 is the smallest protein of the D/R12 subfamily and selectively interacts with Gαi proteins. It is widely expressed in many cells and tissues, with the highest expression found in the brain and immune cells. RGS10 expression is transcriptionally regulated via epigenetic mechanisms.

蛋白信号转导调节子 (RGS) 家族成员是调节分子，可作为异源三聚体 G 蛋白的 G α 亚基的 GTP 酶激活蛋白 (GAP) 。 RGS 蛋白能够使 Gi α、Go α 和 Gq α 亚型的 G 蛋白亚基失活。 它们将 G 蛋白驱动为无活性的 GDP 结合形式。 G 蛋白信号调节器 10 属于该家族。 所有 RGS 蛋白都共享一个保守的 120 个氨基酸序列，称为 RGS 结构域。 这种蛋白质与两个相关 G 蛋白亚基 G-alphai3 和 G-alphaz 的活化形式特异性结合，但不能与结构和功能不同的 G-alpha 亚基相互作用。 G 蛋白 …

2015年1月1日 · Regulator of G protein signaling-10 (RGS10), a GTPase-activating protein (GAP) for Gαi3, Gα q, and Gα z, belongs to the D/R12 subfamily based on the homology within the RGS domain and is one of the smallest RGS proteins, outside the RGS box.

2018年1月1日 · The regulator of G protein signaling 10 (RGS10) protein is a regulatory molecule that belongs to a larger family of RGS proteins responsible for altering cellular signaling. Generally, RGS proteins are negative regulators of signal transduction pathways mediated by heterotrimeric G proteins.

RGS10 has emerged as a key regulator of proinflammatory cytokine production in microglia, functioning as an important neuroprotective factor. Although RGS10 is normally expressed in microglia at high levels, expression is silenced in vitro following activation of TLR4 receptor.

RGS10的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为G蛋白信号（RGS）家族成员的调节是充当异的G蛋白G的阿尔法亚基GTP酶激活蛋白（GAP）调节分子。 RGS蛋白能够停用在Gi的αG蛋白亚基，转到α和Gq蛋白的α亚型。 他们驾驶的G蛋白进入它们的无效GDP结合的形式。 G蛋白信号10的稳压器属于这个家庭。 所有RGS蛋白共享一个保守的120个氨基酸的序列被称为RGS域。 这种蛋白质联营特异性地与两个相关G蛋白亚基的G-alphai3和G …