2007年10月22日 · What Im asking is, is can this level of respiratory depression occur if someone is walking around, appears sober, fully capable of carrying on a normal conversation, not nodding off, etc. I tend to think that "dangerous" respiratory depression only occurs when someone is at the point that they are essentially nodding out, barely able to stay awake.

2024年9月26日 · Opioid-associated overdoses and deaths due to respiratory depression are a major public health problem in the US and other Western countries. In the past decade, much research effort has been directed towards the development of G-protein-biased µ-opioid ...

2007年12月20日 · There is a "background" respiratory depression (which is no more dangerous that "respiratory depression" caused by meditation), but that does not seem to be exasperated by sedatives. While I AM discouraging combining benzos and K simply for economic reasons, I want to be clear that it is not a dangerous combo, and that it does bad for the K in ...

2009年6月23日 · I know that the recommended max daily dose is 600 mg. Other than respiratory depression (worse when combined with other CNS dep.), what other ill effects is a person in danger of experiencing? Other than sleepiness? I only increase my dose by 100mg when I am tolerant to the dose I am at.

2007年1月10日 · The feeling of respiratory depression from ketamine is I 99% guarantee you to be in your head. 150mg of ketamine is a decent dose, enough to give you a medium to medium high intensity experience, so I put my money on the …

2013年3月21日 · Extracts heavy in 7-hydroxymitragynine might produce greater respiratory depression than the leaf itself, and those who metabolize mitragynine to 7-hydroxymitragynine more efficiently could be at greater risk. Mitragynine itself may compete with 7-hydroxymitragynine thus moderating the degree of respiratory depression produced.

2010年7月31日 · Two main questions that come to mind about combining using Kratom and Suboxone together is that respiratory depression is something you have to be careful of when using Suboxone, and in order to stay on the Suboxone I need to be able pass drug tests, in order to get my script filled out for more than just one week at a time.

2014年7月21日 · For the most part combining gabanergics and dissociatives is OK, though bringing tramadol into the mix makes it more iffy. Tramadol is an "atypical" opioid, but mixing opiods with gabanergics (benzos/ghb/alcohol) still tends to lead to respiratory depression as far as I know. Be mindful of class interactions when combining drugs.

2022年3月2日 · On the other hand, a study in sheep demonstrated that norbuprenorphine might contribute to the central effect of buprenorphine. In that study, significant respiratory depression was demonstrated after administration of norbuprenorphine . In the present study, norbuprenorphine was measurable in the plasma after 24hr and stayed stable over the ...

2013年6月6日 · I read that there is a respiratory depression risk involved, but i'm not worried about that. It states that it can cause coma/ and or death. Can it only cause death from the respiratory depression or is there other issues involved with mixing the two..