An example plasmid with two areas of antibiotic resistance coding DNA (1,2) and an origin of replication (3).. Plasmid-mediated resistance is the transfer of antibiotic resistance genes which are carried on plasmids. [1] Plasmids possess mechanisms that ensure their independent replication as well as those that regulate their replication number …

2021年1月22日 · Resistance genes were frequently assembled in clusters flanked by MGEs suggesting that multiple types of resistance can be easily transferred from plasmid to plasmid or from plasmid to chromosome 38.

2023年7月10日 · Although no epidemiological studies have quantified the burden of plasmid-mediated resistance on healthcare systems, one survey found that infections caused by pathogens carrying AMR plasmids are ...

A resistance plasmid is any plasmid that carries one or more antibiotic resistance genes (it may also be, for example, a metabolic plasmid, because it encodes a metabolic function, or a virulence plasmid, because it possesses one or more virulence genes. Carriage of one type of gene does not preclude carriage of other types that do not ...

2014年1月30日 · Resistance to antibiotics is a widely used tool in molecular biology, yet scientists rarely stop to think about how much easier it makes our lives.Plasmid transformation into E. coli is a fairly inefficient process– just 1 out of 10,000 cells on average! Without some means of quickly determining which cells successfully received the correct plasmid, scientists would spend hours to …

2017年11月22日 · Conditions for plasmid persistence and elimination. a The concept of resistance reversal. A population initially consists of a mixture of sensitive (blue) and resistant (orange with plasmid) cells.

2023年8月20日 · The selection for antibiotic resistance by the selective pressure of metals is known to be achieved mainly by co-resistance, cross-resistance and co-regulation (Baker-Austin et al., 2006), however, increasing studies have also indicated the role of metal stress in triggering plasmid transfer.

2025年3月18日 · The second hypothesis is consistent with the association of resistance genes with recombinases (IS, integrons), although the way resistance could favor plasmid mobility is less obvious. To test the first hypothesis, we retained the classification of PTUs into AMR+ and AMR− based on whether they originally contained resistance plasmids.

This chapter provides an overview of plasmid classification systems and then describes the various mechanisms of plasmid-mediated resistance to antibacterial agents. The major pathways for the evolution of bacterial resistance plasmids are discussed. In general, plasmid-mediated resistance to antibacterials is a result of three major mechanisms ...

Plasmids represent one of the most difficult challenge for counteracting the dissemination of antimicrobial resistance. They contribute to the spread of relevant resistance determinants, promoting horizontal gene transfer among unrelated bacteria. Undistinguishable plasmids were identified in unrela …