Rilparencel (Renal Autologous Cell Therapy-REACT®) for Chronic Kidney …
The objective of this open-label, phase 2 randomized controlled trial (RCT) is to evaluate participants' responses to rilparencel (Renal Autologous Cell Therapy-REACT®) following bilateral percutaneous kidney injections into the kidney cortex with a prescribed dosing schedule versus redosing based on biomarker triggers.
Stem cell delivery to kidney via minimally invasive ultrasound …
2020年5月5日 · A minimally invasive renal artery injection was therefore developed to enhance cell delivery to kidney. In this study, luciferase expressing human adipocyte derived stem cells (ADSC) were labelled with gold nanorods (GNR) and injected into the renal artery using ultrasound guidance.
Stem cell delivery to kidney - Nature
2020年5月5日 · Ultrasound-guided renal artery injection of GNR-labelled cells demonstrated that this method is feasible, fast and less invasive than the routine renal artery injection using open...
Does the route matter? A preclinical review of mesenchymal …
2023年9月25日 · Local MSC delivery to the kidney include injection directly into renal parenchyma (intra-renal), subcapsular injection, injection into the renal artery as well as transplantation of an MSC sheet onto the kidney (Fig. 1). Moreover, local delivery of MSCs can also be accomplished during ex vivo machine perfusion prior to kidney transplantation
Novel Drug Delivery Technologies and Targets for Renal Disease
2022年6月2日 · Emerging preclinical evidence supports the feasibility of drug delivery technology for the kidney, and recent studies have contributed to building a robust catalog of peptides, proteins, nanoparticles, liposomes, extracellular vesicles, and other carriers that may be fused to therapeutic peptides, proteins, nucleic acids, or small molecule drugs.
Improving Molecular Therapy in the Kidney - PMC - PubMed …
In the past decade, several groups have begun to develop novel injection techniques in mice such as retrograde ureter, renal vein, and direct subcapsular injections to help resolve the issue of gene delivery to the kidney through the blood.
Safety and Feasibility of a Novel Percutaneous Locoregional Injection …
2021年6月19日 · The protocol required hemoglobin, hematocrit, and renal chemistries before and after injection. Intra- and end-procedure intermittent CT scanning took place to guide the injections and assess for bleeding. Renal ultrasonography was performed during post-injection recovery and on day 1 postprocedure to assess for hematoma.
• subcutaneous injection – preferred in patients NOT receiving haemodialysis (HD) to avoid unnecessary vein punctures. • intravenous injection - preferred in HD patients in order to reduce
Intrarenal injection of mesenchymal stem cell for treatment of …
The current project is to explore feasibility of direct intra-renal injection of human bone marrow derived mesenchymal stem cells (hMSC) for treatment of lupus nephritis in mice. The treatment protocol involved aged male BXSB (20 weeks) injected with 1 …
rAAV9 combined with renal vein injection is optimal for kidney …
2014年5月1日 · We report an optimized kidney-targeted gene delivery strategy using recombinant adeno-associated virus (rAAV) administered via retrograde renal vein injection in mice. Renal vein...
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