There are eight basic pathological gaits that can be attributed to neurological conditions: hemiplegic, spastic diplegic, neuropathic, myopathic, Parkinsonian, choreiform, ataxic (cerebellar) and sensory.

During embryonic development and adulthood, Reelin exerts several important functions in the brain including the regulation of neuronal migration, dendritic growth and branching, dendritic spine formation, synaptogenesis and synaptic plasticity.

An antalgic gait is a gait that develops as a way to avoid pain while walking (antalgic = anti- + alge, “against pain”). painful (antalgic) gait may occur if patient is protecting an injury to the foot, ankle, knee hips or pelvis

2023年6月27日 · Reelin signaling depends on the cell type but mostly involves phosphorylation of NF-κB, PI3K, AKT, or JAK/STAT. This review focuses on non-neuronal functions and the therapeutic potential of Reelin, while highlighting secretion, signaling, and functional similarities between cell types.

2024年11月1日 · Reeler, a naturally occurring mutant mouse discovered due to its ataxic phenotype (reeling gait), has been the subject of extensive histological studies for a long time to elucidate the developmental mechanisms of its brain.

Examples of lowest level gait disorders are antalgic gait, arthritic gait, myopathic (waddling) gait, and steppage gait. Middle level gait disorders are caused by ascending or descending sensorimotor tract lesions, cerebellar pathway damage (ataxia), bradykinesia, hyperkinesias (e.g., chorea, tremor), and dystonia.

The brain malformation results in ataxia and loss of balance, manifesting as a reeling gait in mice (hence the name Reelin) and multiple neurological problems in humans. More subtle abnormalities of Reelin signaling may underlie important neurobehavioral disorders in humans.

2024年3月11日 · 08 醉酒步态（reeling gait）： 病因： 常见于酒精中毒或巴比妥类中毒。 表现： 步态蹒跚、摇晃和前后倾斜，但可在窄基底上行走较短距离，给人似要跌倒的感觉，但可立即纠正。

醉酒步态 （reeling gait）： 病因： 常见于酒精中毒或巴比妥类中毒。 表现： 步态蹒跚、摇晃和前后倾斜，但可在窄基底上行走较短距离，给人似要跌倒的感觉，但可立即纠正。

Reelin, a large extracellular protein, plays several critical roles in brain development and function. It is encoded by RELN, first identified as the gene disrupted in the reeler mouse, a classic neurological mutant exhibiting ataxia, tremors and a ‘reeling’ gait.