Rap1，简称Ras相关蛋白1，是一种小G蛋白，属于Ras超家族。 Rap1有两种异构体：Rap1A和Rap1B。 与其他G蛋白一样，Rap1与GTP结合时具有活性，而与GDP结合时无活性。

John R. Austin II (born September 26, 1973), [1] better known by his stage name Ras Kass, is an American rapper. He is a member of the hip hop supergroup The HRSMN, along with Canibus, Killah Priest, and Kurupt in 2014. [2] He is also a member of the group Golden State Warriors with Xzibit and Saafir.

RAS蛋白家族包括四种：KRAS (两种剪切体4a和4b)、HRAS、NRAS；四种蛋白序列相似度很高，在细胞膜内的定位略有差异，但都和癌症发生相关。 其中KRAS激活突变突变最常见，其突变位点包括G12、G13、Q61、A164，几乎出现在了所有常见的肿瘤中，如胰腺癌，结直肠癌，肺腺癌，甲状腺癌，胃癌等。 RAF激酶是一类丝氨酸/苏氨酸蛋白激酶，其家族包括ARAF，BRAF，CRAF。 它还有另外一个名字是MAPKKK，即丝裂原活化蛋白激酶激酶激 …

Rapper from Tripoli, Lebanon. Started rapping in high school influenced by the first voices of Arab rap in Algeria. Studied in France and worked in banking before returning to

2018年5月16日 · Here we report the development of a targeted delivery method that permits specific expression of homologous Ras-family small GTPases (i.e., Ras, Rap2, and Rap1) in different subcellular microdomains, including the endoplasmic reticulum, lipid rafts, bulk membrane, lysosomes, and Golgi complex, in rodent hippocampal CA1 neurons.

Here we review the current models for NMDA-R-dependent AMPA-R trafficking in synaptic plasticity, learning and memory, and mental diseases with learning disability, focusing on the regulation and dysregulation of Ras and Rap signaling …

2018年7月24日 · 论文以“Ras和Rap通过不同亚细胞微区传递双向突触可塑性信号”（Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains）为题发表在神经科学著名期刊《神经元》（Neuron，影响因子14.318）上。 王广福研究员为本文共同第一作者。...

2002年8月23日 · We show that Ras relays the NMDA-R and CaMKII signaling that drives synaptic delivery of AMPA-Rs during long-term potentiation. In contrast, Rap mediates NMDA-R-dependent removal of synaptic AMPA-Rs that occurs during long-term depression. Ras and Rap exert their effects on AMPA-Rs that contain different subunit composition.

In the nervous system, Ras and Rap modulate the proliferation of neural progenitors, development of synapses, and formation or maintenance of plasticity through distinct signaling pathways. Mutations in Ras or Rap and associated regulatory proteins were identified in multiple neurological disorders . Table 1.

Rap属于Ras家族,含有Rap1和Rap2两个亚类。 Rap通过结合GTP或GDP,在激活与失活两种状态之间切换,从而发挥分子开关的功能。 此外,Rap在癌症的发生和发展过程中也发挥着关键作用,它可抑制癌基因Ras诱导的细胞转化;还可通过与其下游靶分子的相互作用,作为细胞信号 ...