The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the surface of the cell to the DNA in …

2023年12月18日 · This review focuses on potentially unique therapeutic approaches that target the basic components of RAF signaling and autophagy in RAS-dependent and RAS …

This resource provides and describes two animated lessons that illustrate the Ras-MAPK (mitogen-activated protein kinase) signal transduction pathway. They are designed for any …

The Ras/Raf/MAPK pathway is probably the best characterized signal transduction pathway in cell biology. The function of this pathway is to transduce signals from the extracellular milieu to the …

RAS, a pivotal upstream protein in the RAF/MAPK pathway, holds the distinction of being the founding member of the extensive RAS superfamily of small GTPases. 70 RAS is extremely …

2023年12月18日 · The most prevalent signaling cascade governed by multi-kinase inhibitors is the mitogen-activated protein kinase (MAPK) pathway, encompassing the RAS-RAF-MAPK …

The canonical RAS/MAPK pathway is tightly regulated by many proteins, attenuators and negative feedback mechanisms. Mutations in regulators like accessory proteins can lead to a …

This literature review will delineate the mechanisms of Ras signaling in the MAPK pathway and its possible oncogenic mutations, illustrate how specific mutations affect the pathogenesis of …

2022年8月15日 · RAS–GTP contacts physically and activates a kinase enzyme called RAF, triggering a signalling cascade that leads to activation of another kinase, MAPK. This enzyme, …

2021年6月8日 · New discoveries and concepts regarding the receptor-driven RAS-MAPK signal transduction have emerged during the last three decades: novel pathway components, …