2024年12月25日 · RAPGEF2 (Rap Guanine Nucleotide Exchange Factor 2) is a Protein Coding gene. Diseases associated with RAPGEF2 include Epilepsy, Familial Adult Myoclonic, 7 and …

鸟嘌呤核苷酸交换因子 (GEF) ，如 RAPGEF2，通过促进 GTP 的获取以维持活性 GTP 结合状态作为 Ras 激活剂，并且是细胞表面受体和 Ras 激活之间的关键联系 (Rebhun 等人，2000 …

Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene. [5][6][7] RAPGEF2 is a cyclic AMP binding protein. [8][9] Members of the …

2013年6月25日 · We propose that Rapgef2 binds and is directly activated by cAMP, leading to GTP loading of Rap1, activation of B-Raf, and the subsequent activation of ERK by MEK, …

2022年4月26日 · The prognostic model based on RAPGEF2 and RAPGEF2-related genes showed an excellent predictive performance in terms of prognosis and immunotherapy …

Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link …

2014年9月5日 · Here we report that the specific upregulation of the Rap1 guanine nucleotide exchange factor, RapGEF2, in migrating neurons corresponds to the timing of this polarity …

2025年1月4日 · Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the …

RAPGEF2 upregulation activated the downstream effectors Rap2 and JNK. In cultured hippocampal neurons, oligomeric Aβ treatment increased the fluorescence intensity of …

This gene has 13 transcripts (splice variants) and 9 paralogues. Sorry, the page request "/Homo_sapiens/Component/Gene/Summary/gene_summary?g=ENSG00000109756;r=4:160025330 …