Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin . The radixin gene has been localized by fluorescence in situ hybridization to 11q23.

The cell cortex serves as a critical nexus between the extracellular environment/cell membrane and the underlying cytoskeleton and cytoplasm. In many cells, the cell cortex is organized and maintained by the Ezrin, Radixin and Moesin (ERM) proteins, which have the ability to interact with both the p …

2025年3月30日 · RDX (Radixin) is a Protein Coding gene. Diseases associated with RDX include Deafness, Autosomal Recessive 24 and Rare Genetic Deafness. Among its related pathways are Sensory processing of sound and Nervous system development. Gene Ontology (GO) annotations related to this gene include RNA binding and cytoskeletal protein binding.

Radixin is a scaffolding protein that is part of the ezrin/radixin/moesin (ERM) family, localizing to the base of stereocilia. Mutations in the gene encoding radixin are associated with human DFNB24 hearing loss.

Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23.

2004年11月1日 · Radixin functions as a membrane–cytoskeletal crosslinkers in actin-rich cell surface structures and is thereby thought to be essential for cortical cytoskeleton organization, cell motility, adhesion and proliferation.

2024年9月16日 · In the nervous system, radixin has been shown to prevent neurodegeneration and axonal growth. The activation of radixin is through phosphorylation of its conserved threonine residues. Radixin functions in cell signaling pathways by binding to membrane proteins and relaying the cell signals into the cells.

1997年1月1日 · The ERM family consists of three closely related proteins, ezrin, radixin, and moesin, that are thought to work as cross-linkers between plasma membranes and actin-based cytoskeletons. Recent analyses of the structure and functions of ERM proteins have revealed that these molecules are involved not only in cytoskeletal organization but also in ...

2012年7月15日 · Here we show that radixin is required for migration of PC3 prostate cancer cells, and that radixin, but not ezrin or moesin, depletion by RNA interference increases cell spread area and cell–cell adhesion mediated by adherens junctions. Radixin depletion also alters actin organization, and distribution of active phosphorylated ezrin and moesin.

2012年7月15日 · Our results indicate that radixin plays an important role in promoting cell migration by regulating Rac1-mediated epithelial polarity and formation of adherens junctions through Vav GEFs. The ERM proteins ezrin, radixin and moesin are adaptor proteins that link plasma membrane receptors to the actin cytoskeleton.