2025年3月30日 · RAD50 (RAD50 Double Strand Break Repair Protein) is a Protein Coding gene. Diseases associated with RAD50 include Nijmegen Breakage Syndrome-Like Disorder and Hereditary Breast Ovarian Cancer Syndrome .

DNA repair protein RAD50, also known as RAD50, is a protein that in humans is encoded by the RAD50 gene. [5] The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1 (also known as Xrs2 in yeast).

2025年3月26日 · The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends.

同源重组修复是精确的修复dsb的方式,mre11-rad50-nbs1(mrn)复合物是参与同源重组修复的关键蛋白,在不同物种之间存在保守性。 从前关于MRN复合物的功能研究主要来源于酿酒酵母和线虫等低等生物,近些年来对哺乳动物MRN复合物的研究提示MRN复合物在高等动物DNA损伤 ...

RAD50 双链断裂修复蛋白： 该基因编码的蛋白质与酿酒酵母 Rad50 高度相似，后者是一种参与 DNA 双链断裂修复的蛋白质。 该蛋白质与 MRE11 和 NBS1 形成复合物。

2022年5月2日 · Combining pathway reconstitution in electron microscopy, biochemical assays and genetic studies, we show that S. cerevisiae Mre11-Rad50 with or without Xrs2 forms higher-order assemblies in...

2000年6月23日 · Rad50cd displays ATPase activity plus ATP-controlled dimerization and DNA binding activities. Rad50cd crystal structures identify probable protein and DNA interfaces and reveal an ABC-ATPase fold, linking Rad50 molecular mechanisms to ABC transporters, including P glycoprotein and cystic fibrosis transmembrane conductance regulator.

MRN（MRE11/RAD50/NBS1）复合体在放射损伤修复通路中扮演着重要的角色，该复合体作为DNA损伤的“感应器”最先识别DNA双链断裂的位点：一方面，MRN可以引起ATM磷酸化级联反应，激活细胞周期检验点；另一方面，MRN作为具有催化活性的核酸酶，直接参与DNA损伤的修复过程。 MRN中的任何一个成员的缺失和突变都会导致基因组的不稳定性和疾病的发生，例如共济失调-毛细血管扩张样疾病等。 因此，MRN复合物的活性必须受到非常精确的调控。 MRE11兼 …

RAD50 is a subunit of the MRE11/RAD50/NBS1 (MRN) complex. The MRN complex is recruited to the site of DNA double-strand breaks (DSBs) as part of the DNA damage response (DDR) and plays a pivotal role in the repair of damage via either the homologous recombination (HR) or non-homologous end-joining (NHEJ) pathways.

2009年3月24日 · Amino acid sequence similarity and overall architecture make Rad50 a member of the structural maintenance of chromosome (SMC) protein family. Like SMC proteins, Rad50 function depends on ATP binding and hydrolysis.