UV excision repair protein RAD23 homolog A is a protein that in humans is encoded by the RAD23A gene. [5] The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair (NER).

2024年12月25日 · RAD23A (RAD23 Homolog A, Nucleotide Excision Repair Protein) is a Protein Coding gene. Diseases associated with RAD23A include Xeroderma Pigmentosum, Variant Type and Xeroderma Pigmentosum Group C. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and DNA repair pathways, full network.

this study identified RAD23A as a novel negative regulator of RIG-I/MDA5 mediated anti-virus response. Determined is the three-dimensional structure of its ubiquitin-like (UbL) domain by X-ray crystallography.

2023年6月1日 · In this function, RAD23 activates the proteolytic activity of the proteasome and engages specifically in well-characterized degradation pathways through direct interactions with E3 ubiquitin-protein ligases and other UPS components. Here, we summarize the past 40 years of research into the roles of RAD23 in NER and the UPS. 1. Introduction.

2009年4月5日 · Rad23, which was originally identified as an important factor involved in the recognition of DNA lesions, also plays a central role in targeting ubiquitylated proteins for proteasomal degradation, an activity that it shares with …

this study identified RAD23A as a novel negative regulator of RIG-I/MDA5 mediated anti-virus response. Title: RAD23A negatively regulates RIG-I/MDA5 signaling through promoting TRAF2 polyubiquitination and degradation.

2023年12月15日 · RAD23A and RAD23B interact similarly with each human Y-family DNA polymerase. The Y-family DNA polymerases – Pol ι, Pol η, Pol κ and Rev1 – are most well-known for their roles in the DNA damage tolerance pathway of translesion synthesis (TLS).

2011年8月15日 · We silenced the XPC, RAD23A or RAD23B genes in HeLa cells for a long period of time by using Epstein Barr Virus-derived plasmids carrying sequences coding for small interfering RNA. XPC silencing confirms an essential role for XPC in DNA repair and cell survival after ultraviolet light irradiation.

Orthologous to human RAD23A (RAD23 homolog A, nucleotide excision repair protein). [provided by Alliance of Genome Resources, Apr 2022] Ubiquitous expression in liver E14.5 (RPKM 50.1), liver E14 (RPKM 45.7) and 28 other tissues See more. Go to reference sequence details. Go to nucleotide: Graphics FASTA GenBank.

RAD23A and RAD23B (600062), the human orthologs of yeast rad23, play distinct roles in nucleotide excision DNA repair (NER) and in the ubiquitin-proteasome system (UPS).