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2022年3月15日 · Rhesus theta (θ) defensin-1 (RTD-1) is a macrocyclic host defense peptide exhibiting antimicrobial and immunomodulatory activities.

2004年5月21日 · The effects of a mammalian cyclic antimicrobial peptide, rhesus theta defensin 1 (RTD-1) and its open chain analogue (oRTD-1), on the phase behaviour and structure of …

2019年11月15日 · Rhesus theta (θ) defensin-1 (RTD-1), a natural macrocyclic antimicrobial peptide, was recently shown to be rapidly fungicidal against clinical isolates of MDR C. …

2000年1月1日 · A recent paper in Science describes the isolation of a novel anti-microbial peptide from rhesus macaque neutrophils and monocytes, termed rhesus theta defensin 1 (RTD-1). …

RTD-1 is a recently discovered cyclic peptide that, like other well-studied antimicrobial peptides, appears to bind to the lipid matrix of cell membrane in the initial stage of activity. We studied …

2001年3月16日 · In contrast to all the other defensins found so far, rhesus theta defensin-1 (RTD-1) is composed of just 18 amino acids with the backbone cyclized through peptide bonds. …

2015年10月5日 · This study aimed to evaluate the therapeutic potential of a novel macrocyclic peptide, rhesus θ-defensin-1 (RTD-1), by characterizing its in vitro antipseudomonal activity …

使用全序列氨基酸扫描结合高效的“一锅”环化折叠方法，我们获得了基于RTD-1的肽，其抑制野生型LF蛋白酶的活性比野生型RTD-1高约10倍（ IC 50 = 43±3 nM，K i = 18±1 nM）。活性最高 …

2017年7月25日 · Rhesus theta defensin-1 (RTD-1) is a macrocyclic host defense peptide with antimicrobial and immunomodulatory activities. Combined with favorable preclinical safety and …