Ribonuclease L or RNase L (for latent), known sometimes as ribonuclease 4 or 2'-5' oligoadenylate synthetase-dependent ribonuclease, is an interferon (IFN)-induced ribonuclease which, upon activation, destroys all RNA within the cell …

2'-5'oligoadenylate-dependent ribonuclease L (RNase L) is one of the key enzymes involved in the function of interferons (IFNs), a family of cytokines participating in innate immunity against viruses and other microbial pathogens. Upon binding with its …

核糖核酸酶L（ribonuclease L,RNase L）属于2-5腺苷酸（2-′5′oligoadenylate,2-5A）系统,以往研究表明干扰素（interferon,IFN）抗病毒作用以及前列腺癌等多种疾病的发生都与RNase L有关,近期研究表明此酶有诱导凋亡的功能,这一功能是其控制病毒感染以及抵抗肿瘤作用的基础。

2020年5月5日 · 两篇文章从RNase L降解mRNA的选择性、核糖体RNA功能的角度对这一问题进行了系统研究。 两文作者都描述了双链RNA病毒感染后，翻译水平的下降的同时mRNA也出现了大量的降解。

2024年12月27日 · Ribonuclease L is an endonuclease that is activated as part of the dsRNA-driven innate immune response. Active RNase L cleaves pathogenic RNAs as a way to eliminate infections. However, there are additional and unexpected ways that RNase L causes changes in the host that promote an immune response and contribute to its role in host defense.

核糖核酸酶 l： 该基因编码干扰素调节的 2-5a 系统的一个组成部分，该系统在干扰素的抗病毒和抗增殖作用中发挥作用。 该蛋白参与先天免疫，对多种 RNA 病毒具有活性，包括流感病毒和 SARS-CoV-2 病毒。

2021年11月29日 · 假性激酶-核糖核酸酶RNase L是一个多结构域核酸内切酶，由N端锚定重复域（ANK）结构域、假性激酶（PK）结构域和C端核糖核酸酶（RNase）结构域串联组成的，在细胞内经寡聚腺苷酸2-5A激活，通过剪切病毒和宿主单链RNA发挥抗病毒活性。

2005年5月22日 · RNase L is an endoribonuclease that requires 2′-5′ oligoadenylates to cleave single-stranded RNA. In this report we present evidence demonstrating a role for RNase L in translation. We identify...

寡腺苷酸合成酶-核糖核酸酶 L 系统（ OAS-RNase L system ）是一种干扰素诱导的人体先天免疫抗病毒途径。 病毒双链 RNA 激活 OAS 酶表达， OAS 合成第二信使 2-5A ，该信使结合并激活核糖核酸酶 RNase L 。

RNase-L is a mediator of type 1 interferon-induced antiviral activity that has diverse and critical cellular roles, including the regulation of cell proliferation, differentiation, senescence and apoptosis, tumorigenesis, and the control of the innate immune response.