Cross-regulation of RNA methylation modifications and R …
2 天之前 · The dual role of m 6 A methylation in R-loop formation and stability. m 6 A is the most prevalent and reversible RNA methylation modification, primarily mediated by the methyltransferase complex composed of METTL3, METTL14, and WTAP during transcription [].In recent years, numerous studies have highlighted the critical role of m 6 A modifications in regulating R-loop formation and stability ...
Principles of RNA methylation and their implications for biology …
2020年11月1日 · The important biological functions of RNA modification represented by m6A have aroused researchers' extensive interest, and RNA methylation has been more and more applied in various fields.
Dynamic RNA methylation modifications and their regulatory …
Science China Life Sciences - Among over 170 different types of chemical modifications on RNA nucleobases identified so far, RNA methylation is the major type of epitranscriptomic modifications...
Reading, writing and erasing mRNA methylation - Nature
2019年9月13日 · RNA methylation to form N 6-methyladenosine (m6A) in mRNA accounts for the most abundant mRNA internal modification and has emerged as a widespread regulatory mechanism that controls gene ...
Recent advances in methylation modifications of microRNA
Despite the encouraging results of the above studies, there are still many questions about the study of miRNA methylation modifications. The first is about the detection method of methylation modification.
Principles of RNA methylation and their implications for ... - PubMed
In recent years, with the discovery of RNA methylation related proteins and the development of high-throughput sequencing technology, the mystery of RNA methylation has been gradually revealed, and its biological function and application value have gradually emerged.
Detection technologies for RNA modifications - Nature
2022年10月21日 · In this review, we summarize the current knowledge about these RNA modification detection technologies and discuss the challenges for the existing detection tools, providing information for a...
RNA modification: mechanisms and therapeutic targets
2023年8月24日 · In this review, we briefly summarized the basic mechanisms of several common RNA modifications, including m6A, m5C, m1A, m7G, Ψ, A-to-I editing and ac4C.
RNA Methylation - an overview | ScienceDirect Topics
RNA methylation, an epigenetic modification that does not alter gene sequence, may be important to diverse biological processes. Protein regulators of RNA methylation include “writers,” “erasers,” and “readers,” which respectively deposit, remove, and recognize methylated RNA.
The emerging role of RNA modifications in the regulation of …
2020年3月24日 · In this review, we discuss our current understanding of the molecular mechanisms underlying the regulation of mammalian mRNA stability by various RNA modifications. Many recent studies have...