Genomic characterization of the RH locus detects complex and …
2018年6月29日 · Clinically relevant exon 4–7 hybrid alleles (RHD*D-CE (4-7)-D) and exon 9 hybrid alleles (RHCE*CE-D (9)-CE) were prevalent in African Americans. This study shows …
Whole-exome sequencing for RH genotyping and alloimmunization risk in ...
2017年8月3日 · WES can be applied for precise RH genotyping, detection of new or uncommon variants, and determination of RHD zygosity. An altered RH genotype is a risk factor for Rh …
Integrated analyses reveal unexpected complex inversion and ...
2024年6月25日 · Complex gene rearrangement events that resulted in unexpressed RhCE protein were identified in a D-- family, despite intact RHCE gene exons. By integration of multiple …
Molecular genetics and clinical applications for RH - PMC
The reason for this interest is that RHAG, a gene located on chromosome 6 (6p11–p21), shares an identical exon structure and major regions of sequence identity with RHD / RHCE. …
The Human Rh50 Glycoprotein Gene - Journal of Biological Chemistry
The Rh (Rhesus) protein family comprises Rh50 glycoprotein and Rh30 polypeptides, which form a complex essential for Rh antigen expression and erythrocyte membrane integrity. This article …
Two large deletions extending beyond either end of the
2017年11月16日 · Using a combination of quantitative PCR and long-range PCR, we examined three distinct deletions affecting parts of the RHD gene in three blood donors. Their RHD …
The Rh protein family: gene evolution, membrane biology, and …
The genes of the human Rh family are located on three chromosomes (Fig. 6a); they share synteny with mouse homologs in both exon–intron structure and the linkage map that …
Machine learning to optimize automated RH genotyping using …
2024年6月11日 · RH genotype matching can potentially mitigate Rh alloimmunization but comprehensive and accessible genotyping methods are needed. We developed RHtyper as …
DEL variants: review of molecular mechanisms, clinical ... - Springer
2023年10月16日 · The Rh blood group system consists of RHD and RHCE gene. Both genes have 10 exons and share an overall 93.8% gene sequence identity (Okuda et al. 2000) but …
DAR, a New RhD Variant Involving Exons 4, 5, and 7, Often in …
In this study, a new RHD variant, DAR, and a new RHCE variant, c eAR, are described in 4 Dutch African Blacks. Serologically, DAR showed weaker reactions with a monoclonal antibody and …