2024年12月25日 · RGS4 (Regulator Of G Protein Signaling 4) is a Protein Coding gene. Diseases associated with RGS4 include Bipolar Disorder and Schizophrenia. Among its related pathways are GPCR downstream signalling and G-AlphaQ Signaling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and G-protein alpha-subunit binding.

Regulator of G protein signaling 4 also known as RGP4 is a protein that in humans is encoded by the RGS4 gene. RGP4 regulates G protein signaling. [5]

2024年9月11日 · rgs4蛋白是g蛋白信号调控中的关键负调控因子，通过促进gα亚基的gtp水解来限制gpcr信号的持续性和强度。 它在神 经系统和心血管系统中发挥着重要作用，其功能异常与多种疾病相关，包括神经障碍和心血管疾病。

g 蛋白信号调节器 4 蛋白与 rgs1 的同一性为 37%，与大鼠 rgs4 的同一性为 97%。该蛋白在异源三聚体 g 蛋白的上游或水平负向调节信号传导，并定位于细胞质中。

2021年6月25日 · Drawing on pharmacological and rescue experiments in MZrgs4, we provide evidence that Rgs4 facilitates signaling mediated by Akt, Erk and mTOR in order to drive axon outgrowth in motoneurons and...

Regulator of G protein signaling 4 (Rgs4) is a signal transduction protein that controls the function of monoamine, opiate, muscarinic, and other G protein-coupled receptors via interactions with Gα subunits. Rgs4 is expressed in several brain ...

rgs4是一种在大脑回路中广泛表达的多功能蛋白，大脑回路能应对机体的病理性疼痛、情绪和动机等行为，基于本文研究，研究人员发现，rgs4在维持 ...

2003年3月28日 · Regulators of G-protein signaling (RGS) proteins are critical for attenuating G protein-coupled signaling pathways. The membrane association of RGS4 has been reported to be crucial for its regulatory activity in reconstituted vesicles and physiological rolesin vivo. In this study, we report that RGS4 initially binds onto the surface of anionic ...

rgs4的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为g蛋白信号传导的调节器（rgs）家族成员是充当异的g蛋白g的阿尔法亚基gtp酶激活蛋白（gap）调节分子。

RGS4 Inhibits Mv1Lu Cell Proliferation and Migration. We thus far have shown that RGS4 expression was upregulated after initiation of epithelial cell tubulation and that constitutive RGS4 expression negatively impacted tubule formation by epithelial cells.