2025年3月30日 · RGS2 (Regulator Of G Protein Signaling 2) is a Protein Coding gene. Diseases associated with RGS2 include Panic Disorder and Anxiety. Among its related pathways are GPCR downstream signalling and G-AlphaQ Signaling. Gene Ontology (GO) annotations related to this gene include GTPase activator activity and beta-tubulin binding.

Regulator of G-protein signaling 2 is a protein that in humans is encoded by the RGS2 gene. [5] [6] It is part of a larger family of RGS proteins that control signalling through G-protein coupled receptors (GPCR).

G 蛋白信号转导调节子 (RGS) 家族成员是调节分子，可作为异源三聚体 G 蛋白的 G α 亚基的 GTP 酶激活蛋白 (GAP) 。 RGS 蛋白能够使 Gi α、Go α 和 Gq α 亚型的 G 蛋白亚基失活。 它们将 G 蛋白驱动为无活性的 GDP 结合形式。 G 蛋白信号调节器 2 属于该家族。 该蛋白质充当骨髓分化的介质，并可能在白血病发生中发挥作用。 [RefSeq 提供，2009 年 8 月]

RGS2 has emerged as a multifunctional RGS protein that regulates multiple G-protein linked signaling pathways. Regulators of G-protein signaling (RGS) proteins enhance the intrinsic rate at which certain heterotrimeric G-protein alpha-subunits hydrolyze GTP to GDP, thereby limiting the duration that alpha-subunits activate downstream effectors.

Regulators of G protein signaling-2 (RGS2) can interact with G-protein coupled receptors to modulate their signaling and provide a molecular basis for RGS2 recognition by cholecystokinin-2 receptor. RGS2 expression was upregulated by LH receptor and FP receptor activation and modulation of partner receptor signaling by RGS2 may require RGS2 ...

2019年12月1日 · RGS2 regulates brown adipose tissue (BAT) by inhibiting two major G protein-coupled receptor (GPCR) pathways – Gq and Gs. Deletion of RGS2 impairs the differentiation of murine brown adipocytes due to elevated Gq/Rho/ROCK signaling. In vivo, RGS2 knock-out mice show an increase in BAT lipolysis and whole-body energy expenditure.

2018年11月22日 · RGS2 is a protein with various modes of action; it was first described as a G0/G1 switch regulatory gene 7 and has been shown to negatively regulate protein translation 8, 9 and assist gene...

RGS2 expression is regulated at the levels of transcription and protein degradation. RGS2 was first identified as an immediate early gene in activated blood mononuclear cells. Subsequent investigations in many cell types identified various stimuli and signaling pathways that induce Rgs2 gene transcription.

2012年9月14日 · Regulator of G protein signaling (RGS) proteins are GTPase accelerating proteins for heterotrimeric G protein α-subunits. RGS2 has recently been shown to have additional G protein-independent functions including control of ion channel currents, microtubule polymerization, and protein synthesis.

小鼠模型中的实验证据表明，G 蛋白信号传导 2 (RSG2) 蛋白水平的高调节因子先于胰岛素抵抗状态。 在同样的情况下，富含饱和脂肪酸的饮食会诱导 RGS2 蛋白表达增加，这与小鼠基础代谢降低有关。 然而，上述内容尚未在人体中进行分析。 因此，在本研究中，我们检查了 RGS2 表达与胰岛素抵抗状态之间的关联。 与抑制胰岛素介导的 Akt Ser 473磷酸化的棕榈酸 (PA) 一起孵育，导致人脐静脉内皮-CS (HUVEC-CS) 细胞中 RGS2 表达增加。 没有 PA 的 RGS2 过表达足以抑 …