2023年9月1日 · Regulated in development and DNA damage-response 1 (REDD1) is a stress-induced protein that controls various cellular functions, including metabolism, oxidative stress, autophagy, and cell fate,...

REDD1 (regulated in development and DNA damage responses 1), a hypoxia-inducible factor-1 target gene, has a crucial role in inhibiting mammalian target of rapamycin complex 1 (mTORC1) signalling during hypoxic stress.

REDD1 (regulated in development and DNA damage responses 1), a hypoxia-inducible factor-1 target gene, has a crucial role in inhibiting mammalian target of rapamycin complex 1 (mTORC1) signalling during hypoxic stress. However, little is known about the signalling pathways and post-translational modifications that regulate REDD1 function.

2022年10月22日 · Our findings reveal that REDD1 plays a crucial role in atypical NF-κB activation and links adipogenesis, meta-inflammation, and insulin resistance.

Regulated in development and DNA damage-response 1 (REDD1) is a stress-induced protein that controls various cellular functions, including metabolism, oxidative stress, autophagy, and cell fate,...

Since its discovery, the protein regulated in development and DNA damage 1 (REDD1) has been implicated in the cellular response to various stressors. Most notably, its role as a repressor of signaling through the central metabolic regulator, the mechanistic target of rapamycin in complex 1 (mTORC1) has gained considerable attention.

REDD1 influences gene expression by modulating key signaling pathways that control mRNA synthesis and stability. While it does not bind DNA directly, it affects transcription through upstream regulators.

2024年7月8日 · Diabetes upregulates the stress response protein REDD1 to suppress signal transduction downstream of the insulin receptor. REDD1 contributes to the pathophysiology of insulin resistance, hepatic steatosis, diabetic retinopathy, and diabetic nephropathy.

REDD1 is ubiquitously expressed at low levels in most adult human and mouse tissues, but is robustly upregulated in response to a variety of cell stresses. REDD1 was discovered and cloned in 2002 by two separate laboratories.

REDD1 (also known as RTP801, DDIT4, or Dig2) is encoded by DNA damage-inducible transcript 4 (DDIT4), located on human chromosome 10q24.33. This gene was initially found to be expressed in response to cellular stresses in 2002 by two independent groups.