Recombination signal binding protein for immunoglobulin kappa J region is a protein that in humans is encoded by the RBPJ gene. [5][6][7] RBPJ [8] also known as CBF1, is the human …

该基因编码的蛋白质是一种在 Notch 信号通路中很重要的转录调节因子。 编码的蛋白质在不与 Notch 蛋白结合时充当阻遏物，在与 Notch 蛋白结合时充当激活剂。 它被认为通过将含有组蛋 …

2025年3月30日 · RBPJ (Recombination Signal Binding Protein For Immunoglobulin Kappa J Region) is a Protein Coding gene. Diseases associated with RBPJ include Adams-Oliver …

2012年5月20日 · We found that RBP-J, the main nuclear transducer of signaling via Notch receptors, augmented Toll-like receptor 4 (TLR4)-induced expression of key mediators of …

2020年4月6日 · Macrophages play pleiotropic roles in maintaining the balance between immune tolerance and inflammatory responses in the gut. Here, we identified transcription factor RBP-J …

Notch/Rbp-j signaling prevents premature differentiation of pancreatic progenitor cells into endocrine and ductal cells during early development of the transgenic pancreas. ETO is part of …

2024年2月7日 · 摘要研究人员发现Msx2-相互作用核靶蛋白(MINT)与Notch的胞内区域竞争结合DNA结合蛋白RBP-J，并抑制Notch信号的转录活性。 虽然MINT缺失突变小鼠在胚胎期致 …

2025年2月11日 · RBP-J-mediated canonical Notch signaling governs retinal cell specification and differentiation, and maintains retinal lamination through the expression of beta-catenin. …

The RBPJ gene provides instructions for making a protein called RBP-J, which is an integral part of a signaling pathway known as the Notch pathway. Notch signaling controls how certain …

2017年6月23日 · Here, using a combination of biochemical/cellular, structural, and biophysical techniques, we demonstrate that endogenous RBP-J and RITA proteins interact in cells, map …