2025年3月30日 · RB1 (RB Transcriptional Corepressor 1) is a Protein Coding gene. Diseases associated with RB1 include Retinoblastoma and Familial Retinoblastoma. Among its related pathways are Defective binding of RB1 mutants to E2F1, (E2F2, E2F3) and Epigenetic regulation by WDR5-containing histone modifying complexes.

2024年6月19日 · RB1 stands as the pioneering discovery in tumour-suppressor genes, marking a pivotal breakthrough in comprehending cancer development. This overview delves into the role of RB1 in both health and disease, exploring its association with the tumourigenesis of various cancers and a distin …

2020年4月2日 · The retinoblastoma tumor suppressor gene (RB1) plays a critical role in coordinating multiple pathways that impact cancer initiation, disease progression, and therapeutic responses.

Hundreds of mutations in the RB1 gene have been identified in people with retinoblastoma, a rare type of eye cancer that typically affects young children. This cancer develops in the retina, which is the specialized light-sensitive tissue at the back of the eye that detects light and color.

2000年7月18日 · RB1 encodes a ubiquitously expressed nuclear protein that is involved in cell cycle regulation (G1 to S transition). The RB protein is phosphorylated by members of the cyclin-dependent kinase (CDK) system prior to the entry into S phase.

2025年3月16日 · Title: Novel insights into RB1 in prostate cancer lineage plasticity and drug resistance. Retinoblastoma-associated protein is important for TRIM24-mediated activation of the mTOR signaling pathway through DUSP2 action in prostate cancer.

Canonically, RB1 regulates cell cycle progression and represents the down-stream target for CDK4/6 inhibitors that are in clinical use. However, newly discovered features of the RB1-pathway suggest new therapeutic strategies to counter resistance and improve precision medicine.

2006年8月28日 · Hereditary retinoblastoma is caused by germline transmission of one mutationally inactivated Rb1 allele and loss of the remaining wild-type allele in somatic retinal cells.

2023年12月20日 · The Rb1 gene, also known as the retinoblastoma gene, is a tumor suppressor gene that plays a crucial role in regulating cell growth and preventing the development of cancer. The gene is located on chromosome 13 and encodes a protein called Rb1.

Hundreds of mutations in the RB1 gene have been identified in people with retinoblastoma, a rare type of eye cancer that typically affects young children. This cancer develops in the retina, which is the specialized light-sensitive tissue at the back of the eye that detects light and color.