RAB27 - Wikipedia
Rab27 is a member of the Rab subfamily of GTPases. Rab27 is post translationally modified by the addition of two geranylgeranyl groups on the two C-terminal cysteines.
Rab27a and Rab27b control different steps of the exosome
2009年12月6日 · We observed that knocking down five Rab proteins (Rab2b, Rab9a, Rab5a, Rab27a and Rab27b) inhibited exosome secretion without major modifications in the secretion …
Rab27a and Rab27b control different steps of the exosome ... - PubMed
Using an RNA interference (RNAi) screen, we identified five Rab GTPases that promote exosome secretion in HeLa cells. Among these, Rab27a and Rab27b were found to function in MVE …
In vivo Roles of Rab27 and Its Effectors in Exocytosis - PMC
The monomeric GTPase Rab27 regulates exocytosis of a broad range of vesicles in multicellular organisms. Several effectors bind GTP-bound Rab27a and/or Rab27b on secretory vesicles to …
Rab27 effectors, pleiotropic regulators in secretory pathways
Rab27, a member of the small GTPase Rab family, is widely conserved in metazoan, and two Rab27 isoforms, Rab27A and Rab27B, are present in vertebrates. Rab27A was the first Rab …
Rab27a dependent exosome releasing participated in albumin …
2020年7月8日 · Here we show that Rab27a expression was upregulated exclusively in tubular epithelial cells (TECs) during proteinuria nephropathy established by adriamycin (ADR) …
Rab27在消化系统肿瘤中的研究进展 - cjco.cn
2021年4月18日 · 本文讨论了Rab27的结构和功能及其在消化系统恶性肿瘤中的作用，旨在为消化系统肿瘤的诊断和治疗提供理论依据。 Rab蛋白包括70多种亚型，几乎存在于所有的真核细 …
Rab27b, a Regulator of Exosome Secretion, Is Associated With
We examined the level of exosome secretion from Rab27-knockdown 58As9 cells by Western blotting and the ability of Rab27b knockdown to suppress PM in 58As9 cells using a mouse …
Rab27b Is Expressed in a Wide Range of Exocytic Cells and …
Rab proteins regulate multiple, complex processes of membrane traffic. Among these proteins, Rab27a has been shown to function specifically in regulated exocytic pathways. However, the …
抑制RAB27a能够抑制三阴乳腺癌细胞的增殖、侵袭和粘附 - PMC
2023年4月8日 · 抑制在外泌体分泌过程中发挥核心作用的RAB27蛋白家族的表达，以探究其对三阴性乳腺癌 (TNBC)细胞生物学功能的影响。 利用荧光定量PCR和蛋白印迹法对比3株三阴性乳 …
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