PYK2 negatively regulates the Hippo pathway in TNBC by
2018年9月24日 · Here, we report that the nonreceptor tyrosine kinase PYK2 positively regulates TAZ and YAP transcriptional activity in triple-negative breast cancer (TNBC). We found that …
PYK2 Links Gqα and G13α Signaling to NF-κB Activation
2001年8月24日 · Placing PYK2 downstream of G-protein activation, a kinase-dead form of PYK2, PYK2 (KD), blocked NF-κB-dependent transcription triggered by signaling through the …
Pyk2 modulates hippocampal excitatory synapses and contributes …
2017年5月30日 · Here we study the role of Pyk2, a non-receptor calcium-dependent protein-tyrosine kinase highly expressed in the hippocampus. Hippocampal-related learning and CA1 …
Induction of Apoptosis after Expression of PYK2, a Tyrosine Kinase ...
In this report we demonstrate that over-expression of PYK2 in both fibroblastic and epithelial cell lines (e.g., rat-1, mouse 10T1/2, swiss 3T3, quail QT6, and human embryonic kidney 293 cells …
Mettl3/Ythdf2 regulate macrophage inflammation and ROS …
2023年12月1日 · METTL3 knockdown enhanced the activation of MAPKs and AKT signaling and upregulation of NOXs through Pyk2. Mettl3 regulates the mRNA stability and expression of …
Pyk2 Amplifies Epidermal Growth Factor and c-Src-induced …
2004年4月23日 · Here, we provide evidence that Pyk2, along with c-Src, facilitates EGFR-mediated Stat3 activation. Pyk2 expression in HeLa cells induces Stat3 reporter gene …
G13alpha-mediated PYK2 activation. PYK2 is a mediator of
2000年8月11日 · Here we show a critical role for the tyrosine kinase PYK2 in muscarinic receptor type 1 and G (12)alpha/G (13)alpha signaling to an SRE reporter gene. A kinase-inactivate …
PYK2 links G (q)alpha and G (13)alpha signaling to NF-kappa B
2001年8月24日 · Placing PYK2 downstream of G-protein activation, a kinase-dead form of PYK2, PYK2 (KD), blocked NF-kappa B-dependent transcription triggered by signaling through the …
Muscarinic receptor stimulation induces TASK1 channel endocytosis ...
Muscarinic receptor stimulation resulted in transient co-localization of Pyk2 and Src at the cell periphery, and expression of kinase dead (KD) Pyk2 and Src, but not Pyk2 and KD Src, …
Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like …
2017年1月2日 · We propose that the PYK2–NEDD4–NDRG1 circuit plays a central role in HER3 degradation, and that dual targeting of EGFR with PYK2/FAK not only inhibits tumor growth, …