Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the PTK2B gene. [5][6] This gene encodes a cytoplasmic protein tyrosine kinase that is involved in calcium-induced …

富含脯氨酸的酪氨酸激酶2（proline-rich tyrosine kinase 2，Pyk2）是黏着斑激酶（focal adhesion kinase，FAK）家族的一员，Pyk2可使多种含SH2结构域的底物蛋白发生磷酸化，从而参与包 …

The protein tyrosine kinase Pyk2 is encoded by PTK2B, a novel Alzheimer’s disease (AD) susceptibility variant, with the PTK2B risk allele being associated with increased mRNA levels, …

Pyk2 is a non-receptor tyrosine kinase highly enriched in forebrain neurons. Pyk2 is closely related to focal adhesion kinase (FAK), which plays an important role in sensing cell contacts …

Nov 14, 2018 · Proline-rich tyrosine kinase 2 (Pyk2) plays essential roles in tumorigenesis and tumor progression. Pyk2 serves as a non-receptor tyrosine kinase regulating tumor cell …

Aug 9, 2022 · Here, we investigated the mechanism by which the protein tyrosine kinase 2-beta (PYK2) functions as a sensor and effector of cellular calcium influx. We show that the linker …

Apr 1, 2024 · PYK2 functions as a signaling hub in various cascades, and its involvement in positive and negative feedback loops enhances signaling robustness, modulates signaling …

摘要： 富含脯氨酸的酪氨酸激酶2（proline-rich tyrosine kinase 2，Pyk2）广泛存在于细胞和组织中，参与多种生理及病理过程，发挥其生物学效应。 Pyk2依赖N-末端、C-末端和中心激酶结 …

Proline-rich tyrosine kinase 2 (Pyk2) is a nonreceptorprotein tyrosine kinase related to focal adhesion kinase (FAK). Pyk2 is activated by an array of stimuli, including G protein-coupled …

Pyk2 is a Ca 2+ -activated non-receptor tyrosine kinase enriched in forebrain neurons and involved in synaptic regulation. Human genetic studies associated PTK2B, the gene coding …