TIGIT/PVRIG通路重新回归视野，与PD-1联用是否给实体瘤治疗带 …
这一通路的另一个抑制性受体PVRIG（Poliovirus receptor-related Ig domain containing protein）于2016年被报道，它由科罗拉多大学Yuwen Zhu课题组与以色列Compugen公司通 …
PVRIG is a novel natural killer cell immune checkpoint receptor …
2021年12月1日 · This study explored the novel immune checkpoint poliovirus receptor-related immunoglobulin domain-containing (PVRIG) in acute myeloid leukemia (AML). We showed …
速递｜同时靶向TIGIT、PD-1和PVRIG三种免疫检查点，联合疗法展 …
2022年12月7日 · pvrig是一种新型b7/cd28样免疫检查点蛋白 ，pvrl2是pvrig的配体。临床前实验结果显示，在对靶向pd-1免疫疗法耐药的患者中，癌细胞中较高的pvrl2水平 ...
乘风TIGIT/PVRIG浪潮，助力肿瘤免疫治疗发展！ - 知乎专栏
2025年2月24日 · 在肿瘤微环境中，tigit与配体cd155 结合，pvrig与配体cd112 结合，会抑制t 细胞的增殖和活化，抑制nk细胞的杀伤作用，并导致肿瘤细胞的免疫逃逸。因此，联合阻断tigit …
The CD112R/CD112 axis: a breakthrough in cancer immunotherapy
2021年9月10日 · An emerging co-inhibitory receptor, CD112R (also called PVRIG), is most commonly expressed on natural killer (NK) and T cells. It binds to its ligand (CD112 or …
CD112R：君实生物从源头发现的全新免疫检查点通路 - PhIRDA
2021年12月6日 · cd112r（pvrig）是一种抑制性免疫检查点，利用cd112r抑制剂与 pd1或 tigit 抑制剂联合治疗,可进一步促进 t 细胞活化,改善临床治疗效果。 CD112R（脊髓灰质炎病毒受体相 …
Blockade of checkpoint receptor PVRIG unleashes anti-tumor ... - PubMed
2021年6月26日 · PVRIG is a recently identified immune checkpoint receptor and blockade of which could reverse T cell exhaustion to treat murine tumor; however, its therapeutic potential …
PVRIG PVR related immunoglobulin domain containing
2025年2月8日 · PVRIG is a novel NK cell immune checkpoint receptor in acute myeloid leukemia. we demonstrate that PVRIG and PVRL2 are expressed in human cancers and the PVRIG …
Blockade of checkpoint receptor PVRIG unleashes anti-tumor …
PVRIG is a recently identified immune checkpoint receptor and blockade of which could reverse T cell exhaustion to treat murine tumor; however, its therapeutic potential via NK cells in mice …
PVRIG Expression Is an Independent Prognostic Factor and a New ...
2023年1月10日 · Among all members of the TIGIT/DNAM-1 axis, PVRIG expression was higher in tumors than in normal liver, was heterogeneous across tumors, and was the only member with …