PU.1 is an essential regulator of the pro-fibrotic system. In fibrotic conditions, PU.1 expression is perturbed in fibrotic diseases, resulting in upregulation of fibrosis-associated genes sets in …

PU.1 expression is increased during granulocyte and macrophage differentiation, while it is decreased during T lymphocyte and B lymphocyte differentiation. The present study reviews …

Jun 3, 2010 · This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by …

PU.1 is an E26 transformation-specific family transcription factor that is required for development of the immune system. PU.1 functions at both early and late stages of lymphoid and myeloid …

Jan 21, 2020 · Here the authors analyse properties of PU.1 DNA-binding in vitro and genome-wide in vivo across different cell types with native or ectopic PU.1 expression, and uncover the …

PU.1 is a member of the transcription factor family Ets that is expressed selectively on B cells, myeloid cells and macrophages. PU.1 regulates the expression of several genes, including …

Jan 30, 2019 · The transcription factor PU.1 is an essential regulator of the pro-fibrotic gene expression program in fibroblasts; PU.1 expression is upregulated in various fibrotic diseases, …

PU.1是ETS转录因子家族 (E26 transformation-specific family)的成员,在机体多种组织发育中发挥重要作用.近年来的研究发现,PU.1不仅在造血谱系的确定和分化中起作用,而且还在机体免疫,脂 …

Nov 17, 2023 · PU.1的基本特征PU.1是一个能够结合DNA的、具有特异性和亚型选择性的转录因子。 它属于Ets家族（Etsfamily），包含一段无序的N端、一个DNA结合域、一个亚胺基末端、 …

PU.1 is a member of the Ets family of transcription factors and activates target genes through the purine-rich PU-box (1). PU.1 plays a pivotal role in the differentiation of myeloid cells and …