PU.1 is an essential regulator of the pro-fibrotic system. In fibrotic conditions , PU.1 expression is perturbed in fibrotic diseases, resulting in upregulation of fibrosis-associated genes sets in fibroblasts .

PU.1 expression is increased during granulocyte and macrophage differentiation, while it is decreased during T lymphocyte and B lymphocyte differentiation. The present study reviews and discusses the effects of the transcription factor PU.1 on immune cell differentiation.

PU.1, a transcription factor member of the E26 transformation-specific family, affects the function of a variety of immune cells in several physiological and pathological conditions.

2010年6月3日 · This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein–protein interactions with ...

The transcription factor PU.1, the product of the Spi-1 protooncogene, is a hematopoietic-specific member of the ets family that is expressed principally in monocytes/macrophages and B lymphocytes (Macleod et al., 1992). Screening of a B cell cDNA expression library using radiolabeled PU.1 protein as a probe isolated a number of clones ...

1999年4月1日 · PU.1 is a member of the transcription factor family Ets that is expressed selectively on B cells, myeloid cells and macrophages. PU.1 regulates the expression of several genes, including those encoding immunoglobulins, receptors and enzymes.

2024年11月5日 · In addition to its critical involvement in regulating the function of hematopoietic stem cells, PU.1 has been shown to regulate myeloid and lymphoid development in a graded manner with high levels of PU.1 favoring monocyte development and low expression levels inducing B cell fate.

PU.1 is an E26 transformation-specific family transcription factor that is required for development of the immune system. PU.1 functions at both early and late stages of lymphoid and myeloid differentiation. At least 110 direct target genes of PU.1 have …

2020年10月21日 · PU.1 expression is increased during granulocyte and macrophage differentiation, while it is decreased during T lymphocyte and B lymphocyte differentiation. The present study reviews and discusses the effects of the transcription factor PU.1 on …

2020年1月21日 · Establishing gene regulatory networks during differentiation or reprogramming requires master or pioneer transcription factors (TFs) such as PU.1, a prototype master TF of hematopoietic lineage...