mIGV-001 and hIGV-001 were analyzed for extracellular ATP and high mobility group box 1 (HMGB1) as indicators of immunogenic cell death (ICD), along with flow cytometric analysis of viability, surface calreticulin, and reactive oxygen species. Stress and cell death-related pathways were analyzed by immunoblotting.

2023年12月7日 · IGV-001, the first product of the Goldspire™ platform, is a first-in-class autologous immunotherapeutic product that combines personalized whole tumor-derived cells with an antisense oligonucleotide (IMV-001) in implantable biodiffusion chambers, with the intent to induce a tumor-specific immune response in patients with ndGBM.

2021年4月1日 · We evaluated IGV-001, which combines autologous glioblastoma tumor cells and an antisense oligonucleotide against IGF type 1 receptor (IMV-001), in newly diagnosed glioblastoma. Patients and methods: This open-label protocol was approved by the Institutional Review Board at Thomas Jefferson University.

We recently evaluated IGV-001 in patients with newly diagnosed glioblastoma. 1 In a subgroup of IGV-001-treated, Stupp-eligible patients 2 with methylated O6-methylguanine–DNA methyl-transferase (MGMT) promoter, median progression free survival was 38.4 months 1 compared with 8.3 months in historical standard-of-care-treated patients (p=0. ...

2006年11月16日 · Patients (pts) with unmutated (unmut) IgVH gene show a shorter progression free survival and overall survival than the patients with IgVH mutated (mut). To understand the differences between molecular subgroups of B-CLL we have studied transcriptomic and proteomic profiles on samples from 40 B-CLL pts (Binet stage A).

2021年1月27日 · IGV-001 is a first-in-class personalised immunotherapy that uses the patient’s own tumour cells combined with an antisense molecule to induce a potent immune response. The treatment comprises irradiated autologous glioma cells with an antisense oligodeoxynucleotide directed at the insulin-like growth factor type one receptor (IGF-1R) named ...

2024年3月18日 · 本文详细介绍了ChIP-seq、DAP-seq、ATAC-seq和CUT&Tag等技术在生物学研究中的作用，重点讲解了如何利用IGV工具进行转录因子结合、组蛋白修饰等信号的可视化。

2024年10月4日 · igv.js是一个用于Web环境下的高性能基因组数据可视化工具，特别适用于展示基因组数据，如基因变异、序列、注释等。通过ipyigv，研究人员和开发者可以在Jupyter环境（包括Jupyter Notebook和JupyterLab）中方便地嵌入...

Use igv.js to embed an interactive genome visualization component in your web app. A Python package that wraps igv.js for embedding in an IPython notebook. Supports both Jupyter and Google Colab. Generate self-contained HTML reports that consist of a table of genomic sites and associated IGV views for each site.

Instruct IGV to process the new genome and genome feature file to create an IGV formatted genome out... In IGV, which is required when using a genome file that is * not* already preloaded in IGV?