2024年12月25日 · PTGDS (Prostaglandin D2 Synthase) is a Protein Coding gene. Diseases associated with PTGDS include Intracranial Hypotension and Normal Pressure Hydrocephalus. Among its related pathways are Fatty acid metabolism and …

β-Trace protein (BTP), also known as lipocalin prostaglandin D2 synthase (L-PGDS; encoded by the PTGDS gene), is a low-molecular-weight glycoprotein and an emerging novel marker of glomerular filtration rate.

Here, we aimed to explore the expression and function of PTGDS in diffuse large B-cell lymphoma (DLBCL), especially the potential role of PTGDS inhibitor, AT56, in lymphoma therapy. Remarkable high expression of PTGDS was found in DLBCL, which was significantly correlated with poor prognosis.

2021年11月6日 · Here, we aimed to explore the expression and function of PTGDS in diffuse large B-cell lymphoma (DLBCL), especially the potential role of PTGDS inhibitor, AT56, in lymphoma therapy....

2023年11月23日 · PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain.

2024年9月17日 · Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt-β-catenin-STAT3 signaling. Lipocalin-type prostaglandin D synthase levels increase in patients with narcolepsy and idiopathic hypersomnia.

2025年2月8日 · Ptgds is targeted and repressed by the CUL4B/PRC2 complex. Thermodynamic and nuclear magnetic resonance analyses demonstrated that L-PGDS binds to nicotinamide coenzymes, including NADPH, NADP (+), and NADH. Prostaglandin D2 synthase is a novel MR target gene in adipocytes.

2023年2月13日 · One of the most abundant transcripts encoding secreted proteins in oligodendrocyte-lineage cells is Ptgds, encoding lipocalin-type prostaglandin D synthase (L-PGDS; Zhang et al., 2014; Zhang et al., 2016).

2020年11月5日 · Introduction: Prostaglandin D2 Synthase (PTGDS), a member of lipocalin superfamily, plays a dual role in catalyzing the conversion of PGH2 to PGD2 and transporting lipophilic substances. PTGDS protein is with different degrees of glycosylation. AT56 is a selective, competitive, and highly bioavailable inhibitor of PTGDS.

2013年5月13日 · Prostaglandin D2 (PGD2) functions as a neuromodulator and/or trophic factor in the central nervous system. Glutathione (GSH)-independent PGD synthase catalyzes the conversion of prostaglandin H2 (PGH2) to PGD2 in the presence of various sulfhydryl compounds. The enzyme is responsible for biosynthesis of PGD2 in the brain (Nagata et al., …