Phospho-Stat1 (Tyr701) (58D6) Rabbit mAb detects endogenous levels of Stat1 only when phosphorylated at tyrosine 701. The antibody detects phosphorylated tyrosine 701 of p91 Stat1 and also the p84 splice variant. It does not cross-react with the corresponding phospho-tyrosines of other Stat proteins. Human, Mouse.

Activation of STAT1 is directly downstream of cytokine receptors that signal from specific pro-inflammatory cytokines known to be dysregulated in schizophrenia, such as IFNγ, IL6, IL2, and IL10, as well as hypoxia, viral/bacterial infections and peptide growth factors.

STAT3的乙酰化也可能通过STAT3与 丙酮酸脱氢酶复合物 （PDC）亚基E1（PDC-E1）的相互作用促进线粒体能量调节。 PDC是一种连接糖酵解和三羧酸（TCA）循环的线粒体酶，STAT3与PDC的结合加速丙酮酸进入TCA循环，并进一步增加癌细胞中ATP的合成。 此外，STAT5还通过增加HIF1α的水平来促进Warburg效应，HIF1α驱动丙酮酸脱氢酶激酶亚型1（PDK1）的产生，从而阻止丙酮酸进入TCA循环，并将代谢转移到乳酸产生。 此外，磷酸化的STAT5与线粒体中 …

2021年5月14日 · We generated heterozygous mutants in diploid HAP1 cells using CRISPR/Cas9 base-editing, targeting the endogenous STAT1 gene. Our models recapitulated the molecular phenotype of elevated pSTAT1,...

磷酸化的STAT1 (p-STAT1)形成同源或异源二聚体进入细胞核，可调控靶基因表达。 STAT蛋白在产生后分布于胞质中，作为潜在的转录因子，需要磷酸化才能滞留在细胞核中。 未磷酸化的STAT蛋白会穿梭于细胞质和细胞核之间等待激活信号。 一旦磷酸化激活了的STAT蛋白达到细胞核，就会识别带有γ激活序列（GAS）的启动子，来激活这些干扰素诱导的基因表达。 可检测样本中人的p-STAT1，且与其类似物无明显交叉反应。 由于实验操作条件的不同（ 如操作者、移液 …

Levels of activated STAT1 (Y701), i.e. phosphorylated STAT1 (pSTAT1), were measured by a commercially available ELISA in nuclear extracts from PBMCs. Results: There was a significant bimodal distribution in the sample, with an SZ subgroup expressing significantly greater levels of activated pSTAT1 than the remainder of the participants.

In the present study, we evaluated the mechanisms of programmed death ligand 1 (PD‑L1) expression in the breast cancer microenvironment, focusing on the role of interferon‑γ (IFN‑γ), and the clinical indications for anti‑programmed cell death 1 (PD‑1) /anti‑PD‑L1 immunotherapy.

The increased expression of pSTAT1 strongly correlated with T-bet expression in CD4+ and CD8+ cells and monocytes from patients in relapse and was associated with an increased production of IFN-gamma by peripheral blood mononuclear cells (PBMCs). pSTAT3 was also up-regulated in CD4+ and CD8+ cells and monocytes from patients in relapse and was ...

4 天之前 · Phospho-Stat1 (Tyr701) Antibody detects endogenous levels of Stat1 only when phosphorylated at tyrosine 701. The antibody detects phosphorylated tyrosine 701 of p91 Stat1 and also the p84 splice variant. It does not cross-react with the corresponding phospho-tyrosines of other Stat proteins.