PSAT1 Gene - GeneCards | SERC Protein | SERC Antibody
2025年3月30日 · PSAT1 (Phosphoserine Aminotransferase 1) is a Protein Coding gene. Diseases associated with PSAT1 include Phosphoserine Aminotransferase Deficiency and Neu-Laxova Syndrome 2. Among its related pathways are serine and glycine biosynthesis and One-carbon metabolism and related pathways.
PSAT1 - Wikipedia
Phosphoserine aminotransferase (PSA) also known as phosphohydroxythreonine aminotransferase (PSAT) is an enzyme that in humans is encoded by the PSAT1 gene. [5] The protein encoded by this gene is likely a phosphoserine aminotransferase, based on similarity to proteins in mouse, rabbit, and Drosophila.
封面文章 | 磷酸丝氨酸氨基转移酶1（PSAT1）促进肺腺癌EGFR …
2022年10月10日 · 敲低PSAT1能优先抑制耐药细胞的增殖及运动，恢复耐药细胞对Erlotinib的敏感性，增强Erlotinib对肺腺癌的杀伤作用。反之过表达PSAT1可促进肺腺癌Erlotinib耐药和肿瘤转移。
Targeting PSAT1 to mitigate metastasis in tumors with p53
2023年2月15日 · Here, we revealed a moonlighting role of PSAT1 in which PSAT1 interacted with the p53 72P variant to regulate mitochondrial function and thus drive cell metastasis, indicating a critical role...
PSAT1 phosphoserine aminotransferase 1 [ (human)] - National …
2025年2月9日 · PSAT1 promotes autophagy to resist insufficient autophagy caused by cigarette smoke extract in human airway epithelial cells. Overexpression of PSAT1 is Correlated with Poor Prognosis and Immune Infiltration in Non-Small Cell Lung Cancer.
The unique catalytic properties of PSAT1 mediate metabolic
2024年8月27日 · Mechanistically, we find that phosphoserine aminotransferase 1 (PSAT1) has a unique capacity for sustained α-KG production when glutamate is depleted. Breast cancer...
Interplay between acetylation and ubiquitination controls PSAT1 …
2024年10月21日 · Phosphoserine aminotransferase 1 (PSAT1) is a key enzyme in de novo serine synthesis. However, little is known about the mechanisms underlying PSAT1 degradation. We...
Phosphoserine Aminotransferase 1: A Metabolic Enzyme Target of …
Phosphoserine aminotransferase 1 (PSAT1) catalyzes 3-phosphohydroxylpyruvate and glutamate into 3-phosphoserine and α-ketoglutamate. It integrates metabolic pathways critical for cell proliferation, survival, migration and epigenetics, such as glycolysis, de novo serine synthesis, citric acid cycle …
PSAT1 is regulated by ATF4 and enhances cell proliferation via the ...
2017年12月8日 · PSAT1, which is overexpressed in ER-negative breast cancers, is activated by ATF4 and promotes cell cycle progression via regulation of the GSK3β/β-catenin/cyclin D1 pathway.
专家点评Cancer Research封面文章 | 沈瑛课题组揭示PSAT1促进肺 …
2022年10月5日 · 如封面所示：磷酸丝氨酸氨基转移酶1（PSAT1）就像高速运转的机械转盘，上方装载灵活精巧的机械手臂（代谢酶活性）调控细胞内氧化还原平衡（红、蓝气泡），下方装载伸缩自如的椭圆吸盘（蛋白互作功能），募集并激活IQGAP1-STAT3信号轴（紫-粉蛋白卡通 ...