Proton beam radiation induces DNA damage and cell apoptosis …
2015年9月10日 · Our study shows that proton radiation induces more robust DNA damage, cytotoxicity and cell apoptosis than photon radiation, for the first time when using characterized cancer stem cells.
Proton beam radiation induces DNA damage and cell apoptosis …
2015年9月10日 · Our study shows that proton radiation induces more robust DNA damage, cytotoxicity, and cell apoptosis than photon radiation, for the first time when using characterized cancer stem cells. We reveal that this enhanced efficacy is associated with increased DNA damage, reduced DNA repair, altered cell cycle distribution, and increased caspase-3 ...
The Radiobiological Effects of Proton Beam Therapy: Impact on …
Here, we provide an up-to-date review on the radiobiological effects of PBT versus photon radiotherapy in cells, particularly in the context of DNA damage. We also review the DNA repair pathways that are essential in the cellular response to PBT, with a specific focus on the signaling and processing of CDD induced by high-LET protons.
Proton beam radiation induces DNA damage and cell apoptosis …
2015年9月10日 · Compared with photon radiation, proton beam irradiation induces more single and double strand DNA breaks, less H2AX phosphorylation, increased Chk2 phosphorylation, and reduced cell cycle recovery from G2 arrest, leading to caspase-3 activation, PARP cleavage, and cell apoptosis. Furthermore, proton radiation generates a large quantity of ...
Proton radiation induces robust generation of ROS to induce cytotoxicity. Radiation induces DNA damage and cytotoxicity through direct DNA breaks and indirectly through the genera-
Clinical Progress in Proton Radiotherapy: Biological Unknowns
2021年2月3日 · Proton radiation may lead to differential damages and activation of biological processes. Here, we will review the current knowledge of proton radiobiology in terms of induction of reactive oxygen species, hypoxia, DNA damage response, as well as cell death after proton irradiation and radioresistance.
New insights in the relative radiobiological effectiveness of proton ...
2018年1月16日 · Proton therapy is one of the newer radiation treatment modalities and in contrast to the conventional radiotherapy with X-rays, proton beams can be deposited in precise areas with minimal lateral scattering in tissue, which reduces the irradiation to the healthy tissue surrounding the tumor providing reduced side effects [2,3,4].
Proton irradiation induced reactive oxygen species promote ...
2022年12月1日 · Low energy protons increase over-production of mitochondrial ROS in HepG2. HepG2 DNA damages induces G 2 /M cell cycle arrest followed by apoptosis. Proton radiation alters the plasma membrane ultrastructure of HepG2 cells. The increased use of proton therapy has led to the need of better understanding the cellular mechanisms involved.
Proton beam radiation induces DNA damage and cell apoptosis …
2015年9月10日 · Our data reveal a ROS-dependent mechanism by which proton radiation induces DNA damage and cell apoptosis in GSCs. Thus, proton therapy may be more efficient than conventional x-ray photon therapy for eliminating GSCs in GBM patients.
Key biological mechanisms involved in high-LET radiation …
Both levels and types of DNA damage determine cell fate, which can include necrosis, apoptosis, senescence or autophagy. Herein, we present an overview of current RT modalities in the light of DNA damage and repair with emphasis on medium to high-LET radiation. Proton radiation is discussed along with its new adaptation of FLASH RT.
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