Ras, from "Rat sarcoma virus", is a family of related proteins that are expressed in all animal cell lineages and organs. All Ras protein family members belong to a class of protein called small …

RAS proteins are binary switches, cycling between ON and OFF states during signal transduction. These switches are normally tightly controlled, but in RAS-related diseases, such as cancer, …

A Ras protein is a type of small GTP binding and hydrolyzing protein that plays a crucial role in regulating signal transduction pathways involved in cell growth, division, and differentiation. …

2024年7月17日 · In this review, we discuss the mechanisms and functions of known RAS effector proteins, provide structural perspectives on RAS-effector interactions, evaluate their …

2003年5月1日 · Recent advances in visualizing and quantifying the interactions of Ras with distinct plasma-membrane microdomains and other subcellular compartments have yielded …

2024年12月5日 · The high-affinity membrane targeted Ras-binding protein depleted Ras proteins through an autophagosome-lysosome-mediated degradation pathway. These studies provide …

The Ras superfamily of small GTP-binding proteins includes >100 proteins that regulate diverse cellular functions, such as proliferation, survival, cytoskeletal dynamics, and molecular and …

Ras proteins were identified through their association with cell transformation. Since then they have been shown to regulate cell growth, differentiation and apoptosis, as well as influencing …

Las proteínas RAS son GTPasas de bajo tamaño molecular localizadas en la cara interna de la membrana plasmática y que pueden pasar del estado activado (unidas a GTP) al estado …

Ras proteins are small GTPases that serve as master regulators of countless signaling cascades involved in particularly diverse cellular processes. Activating mutations in Ras are found in …