The proteasome and its subunits are of clinical significance for at least two reasons: (1) a compromised complex assembly or a dysfunctional proteasome can be associated with the underlying pathophysiology of specific diseases, and (2) they can be exploited as drug targets for therapeutic interventions.

The proteasome is a highly sophisticated protease complex designed to carry out selective, efficient and processive hydrolysis of client proteins. It is known to collaborate with ubiquitin, which polymerizes to form a marker for regulated ...

The proteasome is a multisubunit enzyme complex that plays a central role in the regulation of proteins that control cell-cycle progression and apoptosis, and has therefore become an important target for anticancer therapy.

As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal proteolytic machine responsible for regulated protein degradation in eukaryotic cells. The proteasome’s cellular functions range from general protein ...

The proteasome is responsible for the turnover of most of the cellular protein pool, making it an essential mechanism for cellular health. The proteasome-ubiquitin pathway has been studied widely and is accepted as the main degradation machinery.

2025年3月17日 · Proteasomes also address proteins that are folded incorrectly because of translation errors, or they are encoded by faulty genes or they have been damaged by other molecules in the cytosol. Structure of the Proteasome in the Core Particle (CP) and the Regulatory Particle (RP) as shown in Figure 3.10.2.

The proteasome is a complex protein machinery composed of the 20S core particle and the 19S regulatory particle, and is responsible for ensuring proteostasis by degrading misfolded, aggregated, or damaged proteins. From: Trends in Biochemical Sciences, 2017

2025年3月5日 · The proteasome is a large protein complex in the cytoplasm of eukaryotic and archaeal cells responsible for proteolysis of proteins that have one or more poly-ubiquitin post-translational ...

2017年5月18日 · The 26S proteasome catalyzes the great majority (at least 80%) of the protein degradation in growing mammalian cells, including both the rapid degradation of misfolded and regulatory proteins and most of the slower breakdown …

2018年7月31日 · The proteasome degrades most cellular proteins in a controlled and tightly regulated manner and thereby controls many processes, including cell cycle, transcription, signalling, trafficking and...