Progabide (INN; trade name Gabrene, Sanofi-Aventis) is an analogue and prodrug of γ-aminobutyric acid (GABA) used in the treatment of epilepsy. Via conversion into GABA, …

Progabide, a fatty acid derivative, is a GABA receptor agonist used to treat the symptoms of epilepsy. Mood-stimulating drugs used primarily in the treatment of affective disorders and …

2005年6月13日 · Progabide, a fatty acid derivative, is a GABA receptor agonist used to treat the symptoms of epilepsy. Progabide binds to both GABA A and GABA B receptors located on the …

普罗加胺: 一种AICARFT激动剂药物，由Sanofi (Sanofi)公司最早进行研发，目前全球最高研发状态为批准上市，作用机制: AICARFT激动剂 (AICAR甲酰基转移酶激动剂)，治疗领域: 神经系统 …

普罗加胺是由赛诺菲研发的一种小分子药物，是一种AICAR甲酰基转移酶激动剂。 目前该药物最高研发阶段为批准上市，用于治疗癫痫。

Progabide is a direct GABA receptor agonist that underwent clinical evaluation in the 1980s. Conflicting results from these studies and a continuing risk of hepatotoxicity have combined to …

GABA receptor agonists, e.g. progabide, modify the activity of several brain neuronal systems which are implicated in the pathogenesis of some neuropsychiatric disorders. Thus, alterations …

1984年1月1日 · Progabide has been shown to be effective in various forms of epilepsy in double-blind and long-term clinical trials. The compound exerts a therapeutic action in patients …

Stimulation of GABA receptors (e.g. by progabide, a new GABA receptor antagonist, or by muscimol) enhances the liberation of norepinephrine in limbic forebrain areas of the rat and …

Progabide (PGB) is the first antiepileptic molecule synthesized on a theoretical basis: the gamma-aminobutyric acid- (GABA)-ergic theory of epilepsy. It is a GABA-agonist which can cross the …