2020年4月11日 · We aimed to investigate whether novel imaging using prostate-specific membrane antigen (PSMA) PET-CT might improve accuracy and affect management. Methods: In this multicentre, two-arm, randomised study, we recruited men with biopsy-proven prostate cancer and high-risk features at ten hospitals in Australia.

Total 302 patients with high-risk prostate cancer were randomized into conventional imaging (n = 152) and 68 Ga-PSMA PET-CT (n = 150) arms. 68 Ga-PSMA PET-CT showed significantly higher accuracy (92% vs. 65%, P < 0.0001), sensitivity (85% vs. 38%), and specificity (98% vs. 91%).

Prostate-specific membrane antigen (PSMA) based imaging using PET/CT fusion has been increasingly used for patients with recurrent prostate cancer. In the proPSMA study, Dr. Hofman and colleagues set to determine the role of PSMA PET/CT in pre-treatment staging.

2020年4月11日 · Prostate-specific membrane antigen (PSMA) is a cell-surface glycoprotein overexpressed on prostate cancer cells. Radiolabelled small molecules that bind with affinity to PSMA enable whole-body tumour-specific imaging with PET-CT.

The theranostic concept of PCa based on prostate-specific membrane antigen (PSMA) overexpression, led to the use of PSMA ligands for systemic therapy in patients with metastatic PC. PSMA has emerged as an attractive diagnostics PCa and therapeutic target for small molecule ligands in prostate cancer.

2020年4月3日 · A prospective randomized multicentre study of the impact of gallium-68 prostate-specific membrane antigen (PSMA) PET/CT imaging for staging high-risk prostate cancer prior to curative-intent surgery or radiotherapy (proPSMA study): clinical trial protocol.

Prostate-specific membrane antigen (PSMA) is a cell-surface glycoprotein overexpressed on prostate cancer cells. Radiolabelled small molecules that bind with afnity to PSMA enable whole-body tumour-specific imaging with PET-CT. Emerging data suggest that PSMA PET-CT is an important advance for imaging prostate cancer, particularly.

2019年2月26日 · Prostate-specific-membrane-antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is a new whole body scanning technique that enables visualisation of prostate cancer with high sensitivity.

2019年3月1日 · Prostate-specific-membrane-antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is a new whole body scanning technique that enables visualisation of...

Results from a randomised controlled trial – the ProPSMA Study – involving 300 prostate cancer (PC) patients find that 68Ga-PSMA PET-CT is more accurate than current practice of conventional imaging with CT and Bone Scan and recommends that 68Ga-PSMA scans be introduced into routine clinical practice.