2020年12月2日 · B cells, or B lymphocytes, are an important and complex cell type that plays central roles in humoral immunity against infections, autoimmunity and transplantation.

Joining of a V segment to the D-J H completes the late pro-B cell stage. Pro-B cells become pre-B cells when they express membrane m chains with surrogate light chains in the pre-B receptor. …

2021年11月25日 · We use single-cell transcriptomics/proteomics to identify differentially expressed gene networks across B cell development and correlate these networks with …

2001年12月1日 · In general, pro-B cells express high levels of TdT protein, and detectable levels of TdT protein are dramatically reduced in the pre-B cell stage (LeBien3 and references …

2014年10月1日 · B cell development occurs through a set of stages defined using surface markers. The earliest B cell progenitor is the pre–pro-B cell, which expresses B220 and has …

Early B cell precursors, or pro-B cells, undergo immunoglobulin (Ig) gene rearrangement to generate a unique B cell receptor (BCR). Pro-B cells differentiate into pre-B cells once the …

2022年8月11日 · 2. Early Pro-B cell. This stage is the second stage of B cell development. The V and J gene segments start joining here. Several proteins are expressed in this stage before …

2024年6月12日 · Here we show that large-scale chromatin reorganization distinguishes young and old bone marrow progenitor (pro-) B cells. These changes result in increased interactions …

Human progenitor and B-cell development is a highly regulated process characterized by the ordered differential expression of numerous cell-surface and intra-cytoplasmic antigens.

Controlled by regulatory circuits of specific transcription factor activities, B cell precursors pass through defined stages of development. RAG-dependent rearrangement of V, D, and J heavy …