The pro-peptide of proNGF: Structure formation and …
The pro-peptide of human nerve growth factor (NGF) functions as an intramolecular chaperone during oxidative renaturation of proNGF in vitro and interacts intramolecularly with the mature …
ProNGF\NGF imbalance triggers learning and memory deficits
2013年3月29日 · ProNGF, the precursor of mature nerve growth factor (NGF), is the most abundant form of NGF in the brain. ProNGF and mature NGF differ significantly in their …
Precursor and mature NGF live tracking: one
2016年2月1日 · Here we developed a strategy to fluorolabel both purified precursor and mature neurotrophins (NTs) with a controlled stoichiometry and insertion site. Using a single particle …
人β神经生长因子基因序列与小鼠高度同源。,Nature - X-MOL
从雄性小鼠上颌下腺（MSG）分离出的NGF活性由三种类型的亚基（α，β和γ）组成，这些亚基可以特异性相互作用形成7S，约130,000分子量（Mr）的复合物。 7S复合物包含两条相同的118 …
Nerve Growth Factor: Early Studies and Recent Clinical Trials
Since its discovery, nerve growth factor (NGF) has long occupied a critical role in developmental and adult neuro-biology for its many important regulatory functions on the survival, growth and …
NGF and ProNGF: Regulation of neuronal and neoplastic
Nerve growth factor (NGF) and its precursor (proNGF) are primarily considered as regulators of neuronal function that induce their responses via the tyrosine kinase receptor TrkA and the …
神经生长因子的前世今生 - 知乎 - 知乎专栏
神经生长因子 (nerve growth factor,NGF)在20世纪50年代被发现，Levi—Montgalcini和Cohen证明了它重要的生物活性因子，是外周神经系统和脑细胞的生长、发育和生存所必需的一种蛋白质 …
Conformational Plasticity of proNGF | PLOS One
2011年7月26日 · NGF is translated as a longer precursor known as pre-proNGF, which contains a signal peptide for protein secretion (pre-peptide) that is cleaved upon translocation into the …
Analysis of β-nerve growth factor and its precursor during human ...
2023年6月6日 · β-Nerve growth factor (NGF) is a neurotrophin that plays a critical role in fetal development during gestation. ProNGF is the precursor form of NGF with a distinct...
Processing of Human Nerve Growth Factor β Proprotein in the …
2021年1月5日 · In this study, human pre-pro-NGF-β expressed in N. Benthamiana plant cells, and its processing to NGF-β was assessed. Several reports show in spite of the production of …