Creation of a pre-bleb with balanced salt solution (BSS) prior to the subretinal injection of gene therapy vector has the potential benefit of conserving viral vector . Indeed, in cases where a …

2024年4月2日 · Subretinal injection of RGX-314 was done without a pre-bleb by a wet-laboratory-trained vitreoretinal surgeon. Cohort 1 received 3 × 109 genome copies per eye, cohort 2 …

pre-bleb, a 41-gauge subretinal injection cannula (Dutch Ophthalmic, Inc., Exeter, NH, USA) and foot-pedal assisted control were used to inject BSS subretinally to create a small bleb.

2024年9月1日 · We describe the role of anatomical and physical variables that affect subretinal bleb propagation and shape and their impact on retinal integrity. We highlight the risks …

2024年10月31日 · The diameter of the pre-bleb mimicking SMH in RMM was 1.30 ± 0.16 cm, increasing to 1.98 ± 0.24 cm and 1.83 ± 0.22 cm after bleb propagation with BSS and air, …

¡ These data characterize the intraoperative pressure levels for creating retinal blebs during sub-retinal delivery of gene therapy. ¡ There was slight variation in the intraoperative pressure …

Intraoperative pressure levels for bleb propagation A The maximum injection pressures, recorded in pounds per square inch (psi), for pre-bleb formation were determined for 63 (90%) out of the...

The intraoperative injection pressures in pounds per square inch (psi) were continuously monitored during bleb formation. Note that the pre-bleb injection pressure (8 psi) was higher …

2023年6月23日 · Creation of a pre-bleb with balanced salt solution (BSS) prior to the subretinal injection of gene therapy vector has the potential benefit of conserving viral vector . Indeed, in …

2024年10月31日 · The models with pre-bleb mimicking SMH were selected based on the median value of the diameter of the bleb. Injection of BSS into the bleb formed by BMF