2024年1月1日 · Polyphenols may mitigate bone loss by enhancing osteoclast apoptosis. The effects of polyphenols can be exerted directly on osteoclasts or indirectly through pathways such as activation of NF-κB/RANKL/OPG system in BMSCs.

Polyphenols can safeguard bone integrity through the decreasing of oxidative stress, the reduction of inflammation by proinflammatory signaling and the modulation of osteoblastogenesis/osteoclastogenesis, by an osteoimmunological action.

Polyphenols also seem to inhibit osteoclast formation by inducing secretion of OPG and decreasing RANKL activation of osteoclastogenesis. At the transcription level, they stimulate expression of NF-κB, therefore reducing inflammatory responses [ 67 ].

We demonstrated that polyphenolic compounds inhibit osteoclast differentiation in a dose-dependent manner. Quantitative real-time PCR, immunocytochemistry, and western blotting revealed that osteoclast markers, such as NFATc1, Cathepsin K, and TRAP were inhibited after the addition of polyphenolic compounds during osteoclast differentiation.

Our data demonstrate that dried plum polyphenols directly inhibit osteoclastogenesis, leading to a decrease in osteoclast activity, by downregulating NFATc1 and inflammatory mediators. Dried plums and their polyphenols have been shown to suppress bone resorption by downregulating receptor activator NF-kappaB ligand (RANKL).

2015年11月1日 · Dietary polyphenols (DPs) reduce bone loss through antioxidative and anti-inflammatory actions. DPs reduce oxidative stress, enhancing osteoblastogenesis and suppressing osteoclastogenesis. DPs improve bone structure by …

2008年5月29日 · Our data demonstrate that dried plum polyphenols directly inhibit osteoclastogenesis, leading to a decrease in osteoclast activity, by downregulating NFATc1 and inflammatory mediators. Epidemiological and preclinical studies point to the consumption of diets rich in fruits and vegetables as providing benefit for skeletal health [1, 2].

Using mouse macrophage cells (RAW 264.7), we examined whether tart cherry polyphenols could dose dependently inhibit the proliferation and activity of receptor activator of nuclear factor kappa-B ligand (RANKL) differentiated osteoclasts under inflammatory conditions.

3 天之前 · Recent studies have found that macromolecular polymers modified with polyphenol-structured drugs can form cross-linked networks through metal ion coordination. ... Although the specific mechanisms of inhibiting osteoclast activity and promoting osteogenesis require further investigation, the findings of this study suggest that MBG@D5-Gel is a ...

2022年9月1日 · We demonstrated that polyphenolic compounds inhibit osteoclast differentiation in a dose-dependent manner. Quantitative real-time PCR, immunocytochemistry, and western blotting revealed that osteoclast markers, such as NFATc1, Cathepsin K, and TRAP were inhibited after the addition of polyphenolic compounds during osteoclast differentiation.