We show that group A Streptococcus (GAS) pilus induces a potent release of the proinflammatory cytokines, and further demonstrate that the surface‐exposed backbone pilin and ancillary pilin …

菌毛 的主体由 蛋白质 “菌毛蛋白（pillin）”通过聚合作用（polymerisation）形成，当然其它蛋白，如菌毛与 细胞膜 结合处的蛋白质（anchoring proteins）和促进菌毛组合蛋白质在菌毛的结 …

2023年9月20日 · The pilus is an extracellular structural part that can be detected in some Streptococcus pneumoniae (S. pneumoniae) isolates (type I pili are found in approximately …

2022年6月2日 · In fact, pilus-specific antibodies have been shown to mediate bacterial opsono-phagocytic killing and protection against infection in different animal models. Mora et al. …

2024年8月2日 · Our findings provide the molecular basis for sortase-catalyzed pilus tip assembly that is very likely employed by other Gram-positive bacteria and potential bioengineering …

2024年12月10日 · In this review paper, we have described the importance of the Sortase C (SrtC) protein which is required for pilus assembly and pilin polymerization. We also provide a …

Pili are proteinaceous filaments that are immobilized in the cell wall of Gram-positive organisms. The genes required for pilus assembly form an operon structure. E. faecalis likely assembles …

2022年2月6日 · Here we show that both assembled GAS pili and individual pilus proteins induce a potent release of the proinflammatory cytokines tumor necrosis factor and interleukin-8. We …

2013年2月1日 · Results: Pilus proteins anti-SAN1518, GBS80, and GBS67 inhibited the adherence and invasion of GBS to the lung and cervical epithelial cells. Conclusion: Pilus …

The group A Streptococcus (GAS) pilus is a long, flexible, hair-like structure anchored to the cell surface that facilitates the adherence of GAS to host cells, thus playing a critical role in …