Revivicor (successor to PPL Therapeutics) established the world’s first alpha-gal knockout pigs, the GalSafe™ lineage progenitors. The GalSafe™ line has one gene inactivated and this line is free of the epitope galactose alpha-1-3 galactose (alpha-gal)

2015年11月10日 · Gene-editing technologies have breathed life into the languishing field of xenotransplantation. Surgeons prepare a genetically modified pig lung for transplantation experiments. Credit: Chris...

PPL says the successful cloning of the pigs opens the door to producing modified pigs whose organs and cells can be transplanted into humans. The method used to produce the piglets differs...

2000年3月14日 · The scientists who created Dolly the sheep have announced the birth of five pig clones - the first in the world. Edinburgh-based company PPL Therapeutics hopes such animals will help meet the...

2000年3月3日 · Five piglets have been cloned from an adult female in a significant milestone on the road to successful organ transplants from pigs to humans. The cloning paves the way for the next step towards pig derived xenotransplants—the production of modified or so-called knock-out pigs, whereby a specific gene linked to hyperacute rejection in humans ...

2002年1月1日 · The gene that has been knocked out in the cloned pigs, a -1,3-galactosyltransferase, is responsible for making an enzyme that adds the sugar to the surface of the cells. PPL says that DNA tests on the five female piglets born at the company's subsidiary in Virginia on Christmas Day have shown that one of their two copies of the gene were ...

2002年1月3日 · But Ayares hopes that organs created from PPL pigs could be transplanted into patients within five years. Other approaches to combating the human donor shortage have been successfully tried.

2001年4月17日 · The world's first litter of transgenic cloned pigs has been produced at PPL Therapeutics, the Edinburgh-based biotech company that worked with the Roslin Institute to create Dolly the sheep. The litter of five genetically modified piglets is part of PPL's attempt to advance towards successful transplanting of pig organs into...

2023年12月19日 · A latent virus in the pig heart — porcine cytomegalovirus, or PCMV — became active and “may have contributed to the dysfunction of the transplant,” the medical center said. There was no evidence that the virus had infected Bennett or spread beyond the heart.

2000年8月16日 · Now, two independent research teams have added pigs to the list of species that have been cloned. The results had been awaited eagerly, because pigs' physiological resemblance to humans makes them a potential source of donor organs. Animal scientists have had trouble cloning pigs; techniques used in other livestock didn't work as well.