2024年2月1日 · PhoU is a negative regulator for the Pi-responsive PhoB/PhoR two-component system. PhoU controls responses to phosphate and its counterions, such as Mg 2+ and K +. PhoU controls polyP, impacting stress resistance and persister formation. PhoU homologs exhibit diverse functions, highlighting its versatility.

2023年11月23日 · This review discusses the multifaceted functions of the PhoU protein in bacterial regulation, focusing on its role in coordinating Pi transport with counterions, controlling polyphosphate accumulation, and regulating secondary metabolite biosynthesis and DNA repair.

2024年12月11日 · PhoU proteins are negative regulators of the phosphate response, regulate virulence, and contribute to antibiotic resistance. Staphylococcus aureus has multiple genes encoding PhoU homologs that regulate persister formation and potentially virulence, but the molecular mechanisms of this regulation are not fully understood.

2017年11月1日 · Phosphate control of the biosynthesis of secondary metabolites in Streptomyces is mediated by the two component system PhoR–PhoP. Linked to the phoR–phoP cluster, and expressed in the opposite...

2020年5月26日 · PhoU homologs are one of the determinant factors in the regulation of persister formation and phosphate metabolism in many bacterial species; however, the functions of PhoU homologs exhibit species-specific characteristics. The pathogenesis of Staphylococcus aureus is closely correlated with …

In Escherichia coli, we identified a new persistence gene, phoU, whose inactivation leads to a generalized higher susceptibility than that of the parent strain to a diverse range of antibiotics, including ampicillin, norfloxacin, and gentamicin, and stresses, such as starvation, acid pH, heat, peroxide, weak acids, and energy inhibitors ...

链霉菌次生代谢物生物合成的磷酸盐控制是由双组分系统 PhoR-PhoP 介导的。 与 phoR-phoP 簇相连并以相反方向表达的 phoU 样编码基因与大肠杆菌的 phoU 基因具有较低的同一性。 该 phoU 样基因的表达严格依赖于 PhoP 的激活。 我们分离出一个 PhoU-null 突变体，并使用转录组学和 RNA 测序 (RNA-seq) 程序来鉴定其转录起始位点和调控。 RNA-seq 研究确定了两个转录起始位点，一个位于 phoU 上游，第二个位于 mptA 基因上游。 PhoU 的转录完全依赖于 PhoP，而下 …

PhoU 连同高亲和力、Pi 特异性 ATP 结合盒转运蛋白 PstSCAB 和双组分蛋白 PhoR 和 PhoB，对于大肠杆菌中的 Pi 信号传导是绝对必需的。 关于 PhoU 的作用及其在调节中的功能知之甚少。

Maintenance of cellular phosphate homeostasis is essential for cellular life. The PhoU protein has emerged as a key regulator of this process in bacteria, and it is suggested to modulate phosphate import by PstSCAB and control activation of the phosphate limitation response by the PhoR-PhoB two-component system.

2010年4月1日 · Our latest studies show that P i signaling involves three distinct processes, which appear to correspond to different states of the sensory histidine kinase PhoR: an inhibition state, an activation state, and a deactivation state. We describe a revised model for P i signal transduction of the E. coli Pho regulon.